{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:52:09Z","timestamp":1791420729126,"version":"4.3.3"},"reference-count":35,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"crossref","award":["2011B061300008"],"award-info":[{"award-number":["2011B061300008"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Obstructive sleep apnoea syndrome (OSAS) is a chronic inflammatory disease regulated by T lymphocytes. Our purpose is to assess the pattern of Th17 cells and CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup>Foxp3<jats:sup>+<\/jats:sup>regulatory T (Treg) cells in peripheral blood of patients with OSAS. Fourty-four OSAS men and 20 healthy volunteers were enrolled. Twenty-three patients were classified into mild to moderate group and 21 cases were classified into severe group according to the severity of OSAS. We detected the frequencies of Th17 and Treg and related serum cytokines secretion and expressions of key transcription factors. OSAS patients revealed significant increase in peripheral Th17 number, Th17-related cytokines (IL-17 and IL-6), and ROR<jats:italic>\u03b3<\/jats:italic>t mRNA levels. They also presented a significant decrease in Treg number, Treg-related cytokines (TGF-<jats:italic>\u03b2<\/jats:italic><jats:sub>1<\/jats:sub>), and Foxp3 mRNA levels as compared with normal persons. As a result, the Th17\/Treg ratios were markedly more upregulated in OSAS patients than those in control group. Furthermore, the Th17\/Treg ratio was positively related to the severity of OSAS and serum levels of C-reactive protein. The development of OSAS may be associated with peripheral Th17\/Treg imbalance and characterized by a proinflammatory cytokine microenvironment. These results opened an alternative explanation for the substantial activation of immune cells in OSAS and the development of related complications.<\/jats:p>","DOI":"10.1155\/2012\/815308","type":"journal-article","created":{"date-parts":[[2012,12,31]],"date-time":"2012-12-31T21:05:56Z","timestamp":1356987956000},"page":"1-11","source":"Crossref","is-referenced-by-count":51,"title":["The Treg\/Th17 Imbalance in Patients with Obstructive Sleep Apnoea Syndrome"],"prefix":"10.1155","volume":"2012","author":[{"given":"Jin","family":"Ye","sequence":"first","affiliation":[{"name":"Sleep Disorders Centre and Department of Otolaryngology\u2014Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Street, Guangzhou, Guangdong 510630, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care, Department of Internal Medicine, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Street, Guangzhou, Guangdong 510630, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gehua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sleep Disorders Centre and Department of Otolaryngology\u2014Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Street, Guangzhou, Guangdong 510630, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"Sleep Disorders Centre and Department of Otolaryngology\u2014Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Street, Guangzhou, Guangdong 510630, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Sleep Disorders Centre and Department of Otolaryngology\u2014Head and Neck Surgery, The Third Affiliated 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