{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:05:05Z","timestamp":1780920305229,"version":"3.54.1"},"reference-count":13,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"First Affiliated Hospital of Dalian Medical University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. To observe the disease activity index (DAI) and the colonic mucosa damage index (CMDI), detect the colonic mucosal expression of PPAR<jats:italic>\u03b3<\/jats:italic>, NF-<jats:italic>\u03ba<\/jats:italic>B, and TNF-<jats:italic>\u03b1<\/jats:italic>in rats with ulcerative colitis (UC), and to investigate the protective role of rosiglitazone in UC.<jats:italic>Methods<\/jats:italic>. Sprague-Dawley (SD) rats were divided into three groups: a control group, a rosiglitazone treatment group, and a UC model group. Rats were sacrificed on days 7, 14, 21, or 35 following administration of treatment after enema and DAI, CMDI and colonic expression of PPAR<jats:italic>\u03b3<\/jats:italic>, NF-<jats:italic>\u03ba<\/jats:italic>B, and TNF-<jats:italic>\u03b1<\/jats:italic>were assessed.<jats:italic>Results<\/jats:italic>. In the UC model group, DAI, CDMI and the colonic expression of NF-<jats:italic>\u03ba<\/jats:italic>B and TNF-<jats:italic>\u03b1<\/jats:italic>increased significantly compared to the control group at all timepoints, but PPAR<jats:italic>\u03b3<\/jats:italic>decreased significantly. Furthermore, in the rosiglitazone treatment group, DAI and CMDI decreased significantly on the 14-day, 21-day, and 35-day timepoints compared to the UC model group; the colonic expression of NF-<jats:italic>\u03ba<\/jats:italic>B and TNF-<jats:italic>\u03b1<\/jats:italic>decreased compared to UC model group at all timepoints, but the PPAR<jats:italic>\u03b3<\/jats:italic>expression increased significantly.<jats:italic>Conclusions<\/jats:italic>. Rosiglitazone can alleviate colonic mucosal inflammation and have the protective role on UC by upregulating PPAR<jats:italic>\u03b3<\/jats:italic>expression and downregulating NF-<jats:italic>\u03ba<\/jats:italic>B and TNF-<jats:italic>\u03b1<\/jats:italic>expression.<\/jats:p>","DOI":"10.1155\/2012\/845672","type":"journal-article","created":{"date-parts":[[2012,10,19]],"date-time":"2012-10-19T01:12:04Z","timestamp":1350609124000},"page":"1-8","source":"Crossref","is-referenced-by-count":11,"title":["Influence of Rosiglitazone on the Expression of PPAR<i>\u03b3<\/i>, NF-<i>\u03ba<\/i>B, and TNF-<i>\u03b1<\/i>in Rat Model of Ulcerative Colitis"],"prefix":"10.1155","volume":"2012","author":[{"given":"Jing-Wei","family":"Mao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, Dalian 116011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Ying","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Respiratory, The First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, Dalian 116011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-De","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, Dalian 116011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i33.4145"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S1089-8603(02)00143-X"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00237-9"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.4652"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.093484"},{"issue":"4","key":"6","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1172\/JCI7145","volume":"104","year":"1999","journal-title":"Journal of Clinical Investigation"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1080\/003655298750027001"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1998.00728.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00271-3"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21322"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/34178"},{"issue":"42","key":"12","doi-asserted-by":"crossref","first-page":"32681","DOI":"10.1074\/jbc.M002577200","volume":"275","year":"2000","journal-title":"Journal of Biological Chemistry"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.749"}],"updated-by":[{"DOI":"10.1155\/grp\/9859572","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000}}],"container-title":["Gastroenterology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2012\/845672.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2012\/845672.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2012\/845672.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T01:36:39Z","timestamp":1498008999000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/grp\/2012\/845672\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":13,"alternative-id":["845672","845672"],"URL":"https:\/\/doi.org\/10.1155\/2012\/845672","relation":{},"ISSN":["1687-6121","1687-630X"],"issn-type":[{"value":"1687-6121","type":"print"},{"value":"1687-630X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}