{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T05:45:22Z","timestamp":1771652722823,"version":"3.50.1"},"reference-count":12,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Nephrology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>The common variable immunodeficiency disease (CVID) is the most common symptomatic primary antibody deficiency. It is the most frequently observed cause of panhypogammaglobulinemia in adults. Here, we present a case of systemic amyloidosis that developed secondary to the common variable immunodeficiency disease causing recurrent infections in a young female patient. A 24-year-old female patient, who was under treatment at the gynecology and obstetrics clinic for pelvic inflammatory disease, was referred to our clinic when she was observed to have swellings in her legs, hands, and face. She had proteinuria at a rate of 3.5\u2009gr\/day, and her serum albumin was 1.5\u2009gr\/dl. The levels of immunoglobulins are IgG: 138\u2009mg\/dl, IgA: 22,6\u2009mg\/dl, and IgM: 16,8\u2009mg\/dl. The renal USG revealed that the kidneys were observed to be enlarged. Since the patient had recurrent infections, hypogammaglobulinemia, nephrotic range proteinuria, and enlarged kidneys in the renal USG, she was thought to have type AA amyloidosis and therefore underwent a renal biopsy. The kidney biopsy revealed amyloid (+). So the patient was diagnosed with AA type of amyloidosis secondary to common variable immunodeficiency disease. A treatment regimen (an ACE inhibitor and a statin) with monthly administration of intravenous immunoglobulin was started.<\/jats:p>","DOI":"10.1155\/2012\/860208","type":"journal-article","created":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T21:26:02Z","timestamp":1354137962000},"page":"1-4","source":"Crossref","is-referenced-by-count":7,"title":["A Rare Cause of Secondary Amyloidosis: Common Variable Immunodeficiency Disease"],"prefix":"10.1155","volume":"2012","author":[{"given":"Ali Kemal","family":"Kadiro\u011flu","sequence":"first","affiliation":[{"name":"Department of Nephrology, Faculty of Medicine, Dicle University, 21280 Diyarbak\u0131r, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u015far","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Faculty of Medicine, Dicle University, 21280 Diyarbak\u0131r, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z\u00fclf\u00fckar","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Faculty of Medicine, Dicle University, 21280 Diyarbak\u0131r, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Kayaba\u015f\u0131","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Faculty of Medicine, Dicle University, 21280 Diyarbak\u0131r, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yahya","family":"Avc\u0131","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Dicle University, 21280 Diyarbak\u0131r, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Serdar","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Dicle University, 21280 Diyarbak\u0131r, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Emin","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Faculty of Medicine, Dicle University, 21280 Diyarbak\u0131r, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1006\/clim.1999.4725"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.12.7.825-832.2005"},{"issue":"2","key":"3","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1046\/j.1365-2796.1996.497838000.x","volume":"240","year":"1996","journal-title":"Journal of Internal Medicine"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.53.3.236"},{"issue":"6","key":"5","doi-asserted-by":"crossref","first-page":"847","DOI":"10.3349\/ymj.2005.46.6.847","volume":"46","year":"2005","journal-title":"Yonsei Medical Journal"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3906\/sag-0712-11"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra023144"},{"issue":"1","key":"8","first-page":"52","volume":"2","year":"2004","journal-title":"Turkiye Klinikleri Journal of Nephrology"},{"issue":"5","key":"9","first-page":"346","volume":"12","year":"1992","journal-title":"Turkiye Klinikleri Journal of Medical Sciences"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011012023616"},{"issue":"1","key":"11","first-page":"63","volume":"92","year":"2001","journal-title":"Recenti Progressi in Medicina"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-007-0008-3"}],"container-title":["Case Reports in Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2012\/860208.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2012\/860208.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2012\/860208.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T03:14:13Z","timestamp":1498014853000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crin\/2012\/860208\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":12,"alternative-id":["860208","860208"],"URL":"https:\/\/doi.org\/10.1155\/2012\/860208","relation":{},"ISSN":["2090-6641","2090-665X"],"issn-type":[{"value":"2090-6641","type":"print"},{"value":"2090-665X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}