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Further, several<jats:italic>in vivo<\/jats:italic>studies have demonstrated a role for Nod1 and Nod2 in host defense against bacterial pathogens. Here, we demonstrated that macrophages from NOD1-, NOD2-, and Rip2-deficient mice produced lower levels of TNF-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>\u03b1<\/mml:mi><\/mml:mrow><\/mml:math>following infection with live<jats:italic>Brucella abortus<\/jats:italic>compared to wild-type mice. Similar reduction on cytokine synthesis was not observed for IL-12 and IL-6. However, NOD1, NOD2, and Rip2 knockout mice were no more susceptible to infection with virulent<jats:italic>B. abortus<\/jats:italic>than wild-type mice. Additionally, spleen cells from NOD1-, NOD2-, and Rip2-deficient mice showed unaltered production of IFN-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>\u03b3<\/mml:mi><\/mml:mrow><\/mml:math>compared to C57BL\/6 mice. Taken together, this study demonstrates that NOD1, NOD2 and Rip2 are dispensable for the control of<jats:italic>B. abortus<\/jats:italic>during<jats:italic>in vivo<\/jats:italic>infection.<\/jats:p>","DOI":"10.1155\/2012\/861426","type":"journal-article","created":{"date-parts":[[2011,12,2]],"date-time":"2011-12-02T00:35:30Z","timestamp":1322786130000},"page":"1-5","source":"Crossref","is-referenced-by-count":14,"title":["Nucleotide-Binding Oligomerization Domain-1 and -2 Play No Role in Controlling<i>Brucella abortus<\/i>Infection in Mice"],"prefix":"10.1155","volume":"2012","author":[{"given":"Fernanda S.","family":"Oliveira","sequence":"first","affiliation":[{"name":"Laboratory of Immunology of Infectious Diseases, Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia B.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology of Infectious Diseases, Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario S.","family":"Zamboni","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, School of Medicine of Ribeir\u00e3o Preto-SP, University of S\u00e3o Paulo (FMRP\/USP), 14049-900 Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio C.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology of Infectious Diseases, Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, 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