{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:53:06Z","timestamp":1787503986922,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T00:00:00Z","timestamp":1336953600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01-DA11460"],"award-info":[{"award-number":["R01-DA11460"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01-DA11460"],"award-info":[{"award-number":["R01-DA11460"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Research and Treatment"],"published-print":{"date-parts":[[2012,5,14]]},"abstract":"<jats:p>\n                    Delta opioid agonists enhance antinociceptive effects of mu-opioid agonists in many preclinical assays of acute nociception, but delta\/mu interactions in preclinical models of inflammation-associated pain have not been examined. This study examined interactions between the delta agonist SNC80 [(+)-4-[(\n                    <jats:italic>\u03b1<\/jats:italic>\n                    R)-\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide] and the mu agonist analgesics methadone, morphine, and nalbuphine in an assay of capsaicin-induced thermal allodynia in rhesus monkeys. Thermal allodynia was produced by topical application of capsaicin to the tail. Antiallodynic effects of methadone, morphine, and nalbuphine were evaluated alone or in combination with fixed proportions of SNC80 identical to proportions previously shown to enhance acute thermal antinociceptive effects of these mu agonists in rhesus monkeys (0.9\u2009:\u20091 SNC80\/methadone; 0.29\u2009:\u20091 SNC80\/morphine; 3.6\u2009:\u20091 SNC80\/nalbuphine). Methadone, morphine, and nalbuphine each produced dose-dependent antiallodynia. SNC80 produced partial antiallodynia up to the highest dose tested (5.6\u2009mg\/kg). SNC80 produced a modest, enantioselective, and naltrindole-reversible enhancement of methadone-induced antiallodynia. However, SNC80 did not enhance morphine antiallodynia and only weakly enhanced nalbuphine antiallodynia. Overall, SNC80 produced modest or no enhancement of the antiallodynic effects of the three mu agonists evaluated. These results suggest that delta agonist-induced enhancement of mu agonist antiallodynia may be weaker and less reliable than previously demonstrated enhancement of mu agonist acute thermal nociception.\n                  <\/jats:p>","DOI":"10.1155\/2012\/867067","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T17:05:22Z","timestamp":1337015122000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["Interaction between Mu and Delta Opioid Receptor Agonists in an Assay of Capsaicin-Induced Thermal Allodynia in Rhesus Monkeys"],"prefix":"10.1155","volume":"2012","author":[{"given":"S. Stevens","family":"Negus","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Virginia Commonwealth University, P.O. Box 980613, Richmond, VA 23298, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ember M.","family":"Morrissey","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Virginia Commonwealth University, P.O. Box 980613, Richmond, VA 23298, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Folk","sequence":"additional","affiliation":[{"name":"Chemical Biology Research Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism National Institutes of Health, DHHS, Bethesda, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenner C.","family":"Rice","sequence":"additional","affiliation":[{"name":"Chemical Biology Research Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism National Institutes of Health, DHHS, Bethesda, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","first-page":"547","volume-title":"Opioid analgesics","year":"2005"},{"key":"2","first-page":"443","volume-title":"Opioids: clinical use","year":"2006"},{"issue":"1","key":"3","first-page":"271","volume":"282","year":"1997","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"4","first-page":"297","volume-title":"The d opioid receptor subtypes and pain modulation","year":"2004"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.082685"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.056515"},{"issue":"1","key":"7","first-page":"86","volume":"208","year":"1979","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"8","first-page":"369","volume-title":"Local anesthetics","year":"2005"},{"key":"9","first-page":"341","volume-title":"General anesthetics","year":"2005"},{"issue":"182","key":"10","first-page":"283","year":"2008","journal-title":"Handbook of Experimental Pharmacology"},{"issue":"3","key":"11","first-page":"811","volume":"299","year":"2001","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"12","volume-title":"Inflammatory mediators and modulators of pain","year":"2006"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.106377"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2757"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.052381"},{"issue":"3","key":"16","first-page":"939","volume":"296","year":"2001","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"1","key":"17","first-page":"150","volume":"286","year":"1998","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.138180"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.12.021"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.169276"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.068411"},{"issue":"2","key":"22","first-page":"993","volume":"271","year":"1994","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"1","key":"23","first-page":"259","volume":"290","year":"1999","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"3","key":"24","first-page":"1121","volume":"278","year":"1996","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"2","key":"25","first-page":"496","volume":"285","year":"1998","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"26"},{"issue":"1","key":"27","first-page":"362","volume":"286","year":"1998","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"2","key":"28","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.pbb.2006.09.012","volume":"85","year":"2006","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.11.004"},{"issue":"2","key":"30","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.pbb.2010.07.019","volume":"97","year":"2010","journal-title":"Pharmacology Biochemistry and Behavior"},{"issue":"3","key":"31","first-page":"1261","volume":"266","year":"1993","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1100-8"},{"key":"33","year":"2000"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2235-2"},{"issue":"3","key":"35","first-page":"1339","volume":"275","year":"1995","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.08.035"}],"container-title":["Pain Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/867067.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/867067.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/867067.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T02:52:31Z","timestamp":1607568751000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/prt\/2012\/867067\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,14]]},"references-count":36,"alternative-id":["867067","867067"],"URL":"https:\/\/doi.org\/10.1155\/2012\/867067","relation":{},"ISSN":["2090-1542","2090-1550"],"issn-type":[{"value":"2090-1542","type":"print"},{"value":"2090-1550","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,14]]}}}