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The \n                  disease is much more frequent along the ancient \n                  \u201cSilk Route\u201d extending from Eastern \n                  Asia to the Mediterranean basin, compared with \n                  Western countries. The disease usually starts \n                  around the third or fourth decade of life. Male \n                  sex and a younger age of onset are associated \n                  with more severe disease. Although the \n                  treatment has become much more effective in \n                  recent years, BD is still associated with severe \n                  morbidity and considerable mortality. The main \n                  aim of the treatment should be the prevention of \n                  irreversible organ damage. Therefore, close \n                  monitoring, early, and appropriate treatment is \n                  mandatory to reduce morbidity and mortality. The \n                  treatment is mainly based on the suppression of \n                  inflammatory attacks of the disease using \n                  immunomodulatory and immunosuppressive agents. \n                  In this paper, current state of knowledge \n                  regarding the therapeutic approaches is \n                  outlined. To provide a rational framework for \n                  selecting the appropriate therapy along the \n                  various treatment choices, a stepwise, \n                  symptom-based, evidence-based algorithmic \n                  approach was developed.<\/jats:p>","DOI":"10.1155\/2012\/871019","type":"journal-article","created":{"date-parts":[[2011,10,5]],"date-time":"2011-10-05T19:03:53Z","timestamp":1317841433000},"page":"1-11","source":"Crossref","is-referenced-by-count":23,"title":["New Evidence-Based Treatment Approach in Beh\u00e7et's Disease"],"prefix":"10.1155","volume":"2012","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7049-0170","authenticated-orcid":true,"given":"Erkan","family":"Alpsoy","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venerology, Akdeniz University School of Medicine, 07059 Antalya, 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