{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T14:14:06Z","timestamp":1648649646054},"reference-count":9,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,10,22]],"date-time":"2012-10-22T00:00:00Z","timestamp":1350864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Polish Ministry of Science & Higher Education","award":["N R13 0082 06"],"award-info":[{"award-number":["N R13 0082 06"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bone Marrow Research"],"published-print":{"date-parts":[[2012,10,22]]},"abstract":"Eighty-six patients suffering from hematological malignancies, immunodeficiencies, and aplastic anemias received alloHSCT from unrelated donors. Donors were selected from the BMDW files and further matching was performed according to the confirmatory typing procedure with the use of PCR SSP and that based on sequencing. The time from the clinical request of the donor search to the final decision of clinicians accepting the donor was from 0.3 to 17.8 months (median 1.6). Matching was analyzed at the allele level, and 50, 27, and 9 donor-recipient pairs were 10\/10 matched, mismatched in one or more alleles, respectively. \nIn an univariate analysis we found better survival if patients were transplanted: (i) from donors matched 10\/10 (<\/mml:mo>P<\/mml:mi>=<\/mml:mo>0.025<\/mml:mn><\/mml:mrow>)<\/mml:mo><\/mml:mrow><\/mml:mrow><\/mml:math>, (ii) not from female donor to male recipient (<\/mml:mo>P<\/mml:mi>=<\/mml:mo>0.037<\/mml:mn><\/mml:mrow>)<\/mml:mo><\/mml:mrow><\/mml:math>, (iii) in female donation from those with \u22641 pregnancy than multiparous (<\/mml:mo>P<\/mml:mi>=<\/mml:mo>0.075<\/mml:mn><\/mml:mrow>)<\/mml:mo><\/mml:mrow><\/mml:math>. Notably, it became apparent that duration of the confirmatory typing process affected the survival (HR = 1.138, P<\/mml:mi>=<\/mml:mo>0.013<\/mml:mn><\/mml:mrow><\/mml:mrow><\/mml:math>). \nIn multivariate analysis only the level of matching and the duration of the matching procedure significantly affected the survival. \nIn conclusion, the duration of the matching procedure in addition to the level of matching should be considered as an independent risk factor of survival.<\/jats:p>","DOI":"10.1155\/2012\/873695","type":"journal-article","created":{"date-parts":[[2012,10,22]],"date-time":"2012-10-22T21:06:29Z","timestamp":1350939989000},"page":"1-5","source":"Crossref","is-referenced-by-count":0,"title":["Both Optimal Matching and Procedure Duration Influence Survival of Patients after Unrelated Donor Hematopoietic Stem Cell Transplantation"],"prefix":"10.1155","volume":"2012","author":[{"given":"Sylwia","family":"Mizia","sequence":"first","affiliation":[{"name":"Division of the National Bone Marrow Donor Registry, Lower Silesian Center for Cellular Transplantation, Grabiszynska 105, 53-439 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorota","family":"Dera-Joachimiak","sequence":"additional","affiliation":[{"name":"Division of the National Bone Marrow Donor Registry, Lower Silesian Center for Cellular Transplantation, Grabiszynska 105, 53-439 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malgorzata","family":"Polak","sequence":"additional","affiliation":[{"name":"Division of the National Bone Marrow Donor Registry, Lower Silesian Center for Cellular Transplantation, Grabiszynska 105, 53-439 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Koscinska","sequence":"additional","affiliation":[{"name":"Division of the National Bone Marrow Donor Registry, Lower Silesian Center for Cellular Transplantation, Grabiszynska 105, 53-439 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariola","family":"Sedzimirska","sequence":"additional","affiliation":[{"name":"Division of the National Bone Marrow Donor Registry, Lower Silesian Center for Cellular Transplantation, Grabiszynska 105, 53-439 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Lange","sequence":"additional","affiliation":[{"name":"Division of the National Bone Marrow Donor Registry, Lower Silesian Center for Cellular Transplantation, Grabiszynska 105, 53-439 Wroclaw, Poland"},{"name":"Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.53"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.03.009"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705787"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.09.001"},{"key":"6","first-page":"93","volume-title":"Activity of the National Polish Bone Marrow Donor Registry","year":"2006"},{"key":"8","first-page":"328","volume-title":"Statistical evaluation of HSCT data","year":"2008"},{"key":"1","first-page":"218","volume-title":"Graft versus host disease","year":"2008"},{"key":"9","first-page":"46","volume-title":"The role of HLA in HSCT","year":"2008"},{"issue":"7","key":"2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/sj.bmt.1704865","volume":"35","year":"2005","journal-title":"Bone Marrow Transplantation"}],"container-title":["Bone Marrow Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/873695.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/873695.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/873695.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T05:18:46Z","timestamp":1607577526000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmr\/2012\/873695\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,22]]},"references-count":9,"alternative-id":["873695","873695"],"URL":"https:\/\/doi.org\/10.1155\/2012\/873695","relation":{},"ISSN":["2090-2999","2090-3006"],"issn-type":[{"value":"2090-2999","type":"print"},{"value":"2090-3006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,22]]}}}