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The extract significantly reduced coronary perfusion pressure by up to<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>24.5<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>3.0<\/mml:mn><\/mml:mrow><\/mml:math>\u2009mm\u2009Hg at a 3\u2009mg dose and also reduced heart rate by up to<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>49.5<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>11.4<\/mml:mn><\/mml:mrow><\/mml:math>\u2009beats\/minute at this dose. Five labdane diterpenes, 14-deoxy-12-hydroxyandrographolide (<jats:bold>1<\/jats:bold>), 14-deoxy-11,12-didehydroandrographolide (<jats:bold>2<\/jats:bold>), 14-deoxyandrographolide (<jats:bold>3<\/jats:bold>), andrographolide (<jats:bold>4<\/jats:bold>), and neoandrographolide (<jats:bold>5<\/jats:bold>), were isolated from the aerial parts of this medicinal plant. Bioassay-guided studies using animal model showed that compounds, (<jats:bold>2<\/jats:bold>) and (<jats:bold>3<\/jats:bold>) were responsible for the coronary vasodilatation. This study also showed that andrographolide (<jats:bold>4<\/jats:bold>), the major labdane diterpene in this plant, has minimal effects on the heart.<\/jats:p>","DOI":"10.1155\/2012\/876458","type":"journal-article","created":{"date-parts":[[2012,3,28]],"date-time":"2012-03-28T21:03:25Z","timestamp":1332968605000},"page":"1-5","source":"Crossref","is-referenced-by-count":37,"title":["Cardiovascular Activity of Labdane Diterpenes from<i>Andrographis paniculata<\/i>in Isolated Rat Hearts"],"prefix":"10.1155","volume":"2012","author":[{"given":"Khalijah","family":"Awang","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nor Hayati","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Medicinal Plants Division, Forest Research Institute of Malaysia (FRIM), Kepong, 52109 Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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