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To this end, we developed swatCGH, a data analysis framework and region detection heuristic for computational grids. swatCGH analyses sequentially displaced (sliding) windows of neighbouring probes and applies adaptive thresholds of varying stringency to identify the 10% of each chromosome that contains the most frequently occurring CNAs. We used the method to analyse a published dataset, comparing data preprocessed using four different DNA segmentation algorithms, and two methods for prioritising the detected CNAs. The consolidated list of the most commonly detected aberrations confirmed the value of swatCGH as a simplified high-throughput method for identifying biologically significant CNA regions of interest.<\/jats:p>","DOI":"10.1155\/2012\/876976","type":"journal-article","created":{"date-parts":[[2012,9,14]],"date-time":"2012-09-14T18:11:28Z","timestamp":1347646288000},"page":"1-12","source":"Crossref","is-referenced-by-count":1,"title":["A High-Throughput Computational Framework for Identifying Significant Copy Number Aberrations from Array Comparative Genomic Hybridisation Data"],"prefix":"10.1155","volume":"2012","author":[{"given":"Ian","family":"Roberts","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie A.","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4730-5197","authenticated-orcid":true,"given":"Cinzia G.","family":"Scarpini","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantina","family":"Karagavriilidou","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny C. 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