{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:33:28Z","timestamp":1789878808264,"version":"4.0.1"},"reference-count":291,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Oncology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Between 2000 and 2050, the number of new cancer patients diagnosed annually is expected to double, with an accompanying increase in treatment costs of more than $80 billion over just the next decade. Efficacious strategies for cancer prevention will therefore be vital for improving patients' quality of life and reducing healthcare costs. Judah Folkman first proposed antiangiogenesis as a strategy for preventing dormant microtumors from progressing to invasive cancer. Although antiangiogenic drugs are now available for many advanced malignancies (colorectal, lung, breast, kidney, liver, brain, thyroid, neuroendocrine, multiple myeloma, myelodysplastic syndrome), cost and toxicity considerations preclude their broad use for cancer prevention. Potent antiangiogenic molecules have now been identified in dietary sources, suggesting that a rationally designed antiangiogenic diet could provide a safe, widely available, and novel strategy for preventing cancer. This paper presents the scientific, epidemiologic, and clinical evidence supporting the role of an antiangiogenic diet for cancer prevention.<\/jats:p>","DOI":"10.1155\/2012\/879623","type":"journal-article","created":{"date-parts":[[2011,9,29]],"date-time":"2011-09-29T15:03:35Z","timestamp":1317308615000},"page":"1-23","source":"Crossref","is-referenced-by-count":60,"title":["Tumor Angiogenesis as a Target for Dietary Cancer Prevention"],"prefix":"10.1155","volume":"2012","author":[{"given":"William W.","family":"Li","sequence":"first","affiliation":[{"name":"The Angiogenesis Foundation, One Broadway, 14th Floor, Cambridge, MA 02142, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent W.","family":"Li","sequence":"additional","affiliation":[{"name":"The Angiogenesis Foundation, One Broadway, 14th Floor, Cambridge, MA 02142, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Hutnik","sequence":"additional","affiliation":[{"name":"The Angiogenesis Foundation, One Broadway, 14th Floor, Cambridge, MA 02142, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert S.","family":"Chiou","sequence":"additional","affiliation":[{"name":"The Angiogenesis Foundation, One Broadway, 14th Floor, Cambridge, MA 02142, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"10","key":"2","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/jnci\/93.10.742","volume":"93","year":"2001","journal-title":"Journal of the National Cancer Institute"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq495"},{"issue":"19","key":"4","first-page":"4743","volume":"59","year":"1999","journal-title":"Cancer Research"},{"issue":"1","key":"5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/jnci\/82.1.4","volume":"82","year":"1990","journal-title":"Journal of the National Cancer Institute"},{"issue":"2","key":"6","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1084\/jem.133.2.275","volume":"133","year":"1971","journal-title":"Journal of Experimental Medicine"},{"issue":"21","key":"7","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1056\/NEJM197111182852108","volume":"285","year":"1971","journal-title":"The New England Journal of Medicine"},{"issue":"4","key":"8","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/sj.neo.7900038","volume":"1","year":"1999","journal-title":"Neoplasia"},{"issue":"1","key":"9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nm0195-27","volume":"1","year":"1995","journal-title":"Nature Medicine"},{"issue":"3","key":"10","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/carcin\/21.3.505","volume":"21","year":"2000","journal-title":"Carcinogenesis"},{"issue":"4","key":"11","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1053\/hp.2000.6724","volume":"31","year":"2000","journal-title":"Human Pathology"},{"key":"12","volume-title":"Tumor angiogenesis","year":"2000"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02104.x"},{"issue":"23","key":"14","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1038\/sj.onc.1203589","volume":"19","year":"2000","journal-title":"Oncogene"},{"issue":"8","key":"15","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1182\/blood.V95.8.2637","volume":"95","year":"2000","journal-title":"Blood"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02690.x"},{"issue":"8","key":"17","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1038\/sj.bjc.6693515","volume":"81","year":"1999","journal-title":"British Journal of Cancer"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(96)00396-6"},{"issue":"6","key":"19","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/S0093-7754(01)90021-1","volume":"28","year":"2001","journal-title":"Seminars in Oncology"},{"key":"20","volume-title":"Angiogenesis-based medicine: principles and practice for disease prevention and intervention","year":"2007"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0300rev"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0069"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1038\/nm0297-177"},{"issue":"2","key":"26","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1530\/rep.0.1210181","volume":"121","year":"2001","journal-title":"Reproduction"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1053\/beog.2000.0133"},{"issue":"4","key":"28","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1095\/biolreprod64.4.1033","volume":"64","year":"2001","journal-title":"Biology of Reproduction"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1046\/j.1087-0024.2000.00014.x"},{"issue":"9","key":"30","first-page":"491","volume":"18","year":"2006","journal-title":"Advances in Skin &amp; Wound Care."},{"issue":"4642","key":"31","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1126\/science.6199844","volume":"223","year":"1984","journal-title":"Science"},{"issue":"4587","key":"32","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1126\/science.6823562","volume":"219","year":"1983","journal-title":"Science"},{"issue":"4935","key":"33","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1126\/science.2479986","volume":"246","year":"1989","journal-title":"Science"},{"issue":"2","key":"34","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0002-9440(10)65284-4","volume":"154","year":"1999","journal-title":"American Journal of Pathology"},{"issue":"6626","key":"35","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/386671a0","volume":"386","year":"1997","journal-title":"Nature"},{"issue":"10","key":"36","first-page":"2749","volume":"62","year":"2002","journal-title":"Cancer Research"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1038\/nm740"},{"issue":"4787","key":"38","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1126\/science.2432664","volume":"235","year":"1987","journal-title":"Science"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(19970301)64:3<403::AID-JCB7>3.0.CO;2-Z"},{"issue":"6","key":"40","doi-asserted-by":"crossref","first-page":"H2205","DOI":"10.1152\/ajpheart.1999.277.6.H2205","volume":"277","year":"1999","journal-title":"American Journal of Physiology\u2014Heart and Circulatory Physiology"},{"issue":"12","key":"41","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1242\/jcs.112.12.2049","volume":"112","year":"1999","journal-title":"Journal of Cell Science"},{"key":"42","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0140-6736(94)91280-7","volume":"344","year":"1994","journal-title":"The Lancet"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005766511385"},{"issue":"2","key":"44","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1084\/jem.141.2.427","volume":"141","year":"1975","journal-title":"Journal of Experimental Medicine"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.6.2645"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.2001.2364"},{"issue":"2","key":"47","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1096\/fj.01-0332fje","volume":"16","year":"2002","journal-title":"The Federation of American Societies for Experimental Biology Journal"},{"issue":"2","key":"48","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1078\/0065-1281-00642","volume":"104","year":"2002","journal-title":"Acta Histochemica"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.2001.2311"},{"issue":"3","key":"50","first-page":"1022","volume":"61","year":"2001","journal-title":"Cancer Research"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5425.245"},{"issue":"1","key":"52","first-page":"52","volume":"24","year":"1983","journal-title":"Investigative Ophthalmology and Visual Science"},{"issue":"3","key":"53","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/0002-9394(84)90637-8","volume":"97","year":"1984","journal-title":"American Journal of Ophthalmology"},{"key":"54","first-page":"151","volume":"30","year":"1989","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(94)90027-2"},{"issue":"5178","key":"56","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1126\/science.7521539","volume":"265","year":"1994","journal-title":"Science"},{"issue":"3","key":"57","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000025733","volume":"37","year":"2000","journal-title":"Journal of Vascular Research"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.26.14888"},{"issue":"10","key":"59","doi-asserted-by":"crossref","first-page":"4562","DOI":"10.1073\/pnas.92.10.4562","volume":"92","year":"1995","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"60","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1083\/jcb.104.3.689","volume":"104","year":"1987","journal-title":"Journal of Cell Biology"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.2.1209"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007764200"},{"issue":"9","key":"63","first-page":"2520","volume":"60","year":"2000","journal-title":"Cancer Research"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90200-3"},{"issue":"8","key":"65","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/sj.bjc.6692167","volume":"81","year":"1999","journal-title":"British Journal of Cancer"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.20.10868"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81848-6"},{"issue":"11","key":"68","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.1182\/blood.V95.11.3403","volume":"95","year":"2000","journal-title":"Blood"},{"key":"69","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1101\/SQB.1994.059.01.052","volume":"59","year":"1994","journal-title":"Cold Spring Harbor Symposia on Quantitative Biology"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.11.061"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80108-7"},{"issue":"23","key":"72","first-page":"5822","volume":"53","year":"1993","journal-title":"Cancer Research"},{"issue":"3","key":"73","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0092-8674(89)90238-9","volume":"56","year":"1989","journal-title":"Cell"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10026"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1038\/44334"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1024602"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204896"},{"issue":"3","key":"78","first-page":"141","volume":"13","year":"2002","journal-title":"Cell Growth and Differentiation"},{"issue":"20","key":"79","first-page":"4575","volume":"55","year":"1995","journal-title":"Cancer Research"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.43.25915"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.3.861"},{"issue":"3","key":"82","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0092-8674(00)80664-9","volume":"100","year":"2000","journal-title":"Cell"},{"issue":"5, supplement 16","key":"83","first-page":"27","volume":"28","year":"2001","journal-title":"Seminars in Oncology"},{"issue":"4","key":"84","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0046-8177(99)90117-X","volume":"30","year":"1999","journal-title":"Human Pathology"},{"issue":"2","key":"85","first-page":"462","volume":"61","year":"2001","journal-title":"Cancer Research"},{"issue":"19","key":"86","first-page":"7349","volume":"61","year":"2001","journal-title":"Cancer Research"},{"issue":"2","key":"87","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/jnci\/92.2.143","volume":"92","year":"2000","journal-title":"Journal of the National Cancer Institute"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5422.1994"},{"issue":"2","key":"89","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1093\/jnci\/92.2.94","volume":"92","year":"2000","journal-title":"Journal of the National Cancer Institute"},{"issue":"2","key":"90","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/nm0295-149","volume":"1","year":"1995","journal-title":"Nature Medicine"},{"issue":"10","key":"91","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/S1076-6332(00)80629-7","volume":"7","year":"2000","journal-title":"Academic Radiology"},{"issue":"6015","key":"92","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/315115a0","volume":"315","year":"1985","journal-title":"Nature"},{"key":"93","volume-title":"Expression of the angiogenic phenotype during development of murine and human cancer","year":"1991"},{"issue":"6219","key":"94","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/339058a0","volume":"339","year":"1989","journal-title":"Nature"},{"issue":"6080","key":"95","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/322609a0","volume":"322","year":"1986","journal-title":"Nature"},{"issue":"6","key":"96","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/0092-8674(91)90033-U","volume":"66","year":"1991","journal-title":"Cell"},{"issue":"7","key":"97","first-page":"995","volume":"42","year":"1998","journal-title":"International Journal of Developmental Biology"},{"issue":"11","key":"98","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1101\/gad.13.11.1382","volume":"13","year":"1999","journal-title":"Genes and Development"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0463.2002.100501.x"},{"key":"100","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2001.00986.x"},{"issue":"7","key":"101","first-page":"1294","volume":"57","year":"1997","journal-title":"Cancer Research"},{"key":"102","series-title":"Biology of Tumors","volume-title":"Tumor angiogenesis","volume":"3","year":"1975"},{"issue":"4","key":"103","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/0360-3016(90)90411-C","volume":"18","year":"1990","journal-title":"International Journal of Radiation Oncology Biology Physics"},{"issue":"2","key":"104","first-page":"179","volume":"30","year":"1976","journal-title":"International Journal of Radiation Biology"},{"issue":"2","key":"105","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1084\/jem.136.2.261","volume":"136","year":"1972","journal-title":"Journal of Experimental Medicine"},{"key":"106","doi-asserted-by":"publisher","DOI":"10.1038\/nm0296-167"},{"issue":"2","key":"107","first-page":"336","volume":"54","year":"1994","journal-title":"Cancer Research"},{"issue":"4","key":"108","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/path.1711510413","volume":"151","year":"1987","journal-title":"Journal of Pathology"},{"key":"109","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90187-2"},{"issue":"3","key":"110","first-page":"512","volume":"35","year":"1975","journal-title":"Cancer Research"},{"key":"111","volume-title":"Antiangiogenesis agents","year":"2001"},{"issue":"6","key":"112","first-page":"738","volume":"17","year":"1967","journal-title":"Laboratory Investigation"},{"issue":"4","key":"113","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/bjc.1984.66","volume":"49","year":"1984","journal-title":"British Journal of Cancer"},{"issue":"10","key":"114","first-page":"2470","volume":"30","year":"1970","journal-title":"Cancer Research"},{"issue":"1","key":"115","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0026-2862(77)90141-8","volume":"14","year":"1977","journal-title":"Microvascular Research"},{"issue":"18","key":"116","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1056\/NEJM198905043201807","volume":"320","year":"1989","journal-title":"The New England Journal of Medicine"},{"issue":"6","key":"117","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1517\/13543784.9.6.1383","volume":"9","year":"2000","journal-title":"Expert Opinion on Investigational Drugs"},{"issue":"2","key":"118","first-page":"203","volume":"24","year":"1997","journal-title":"Seminars in Oncology"},{"key":"119","volume-title":"The logic of anti-angiogenic gene therapy","year":"1998"},{"issue":"2","key":"120","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11912-001-0013-8","volume":"3","year":"2001","journal-title":"Current Oncology Reports"},{"issue":"3","key":"121","first-page":"1453","volume":"22","year":"2002","journal-title":"Anticancer Research"},{"issue":"13","key":"122","first-page":"3711","volume":"62","year":"2002","journal-title":"Cancer Research"},{"key":"123","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10316"},{"key":"124","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(93)90246-H"},{"key":"125","volume-title":"Clinical trials of angiogenesis based therapies: overview and new guiding principles","year":"1998"},{"issue":"4","key":"126","first-page":"2061","volume":"22","year":"2002","journal-title":"Anticancer Research"},{"key":"127","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200214105"},{"key":"128","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199702)181:2<200::AID-PATH726>3.0.CO;2-K"},{"issue":"2-3","key":"129","first-page":"95","volume":"429","year":"1996","journal-title":"Virchows Archiv"},{"key":"130","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990611)81:6<845::AID-IJC1>3.0.CO;2-5"},{"issue":"1","key":"131","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1006\/gyno.1997.4835","volume":"67","year":"1997","journal-title":"Gynecologic Oncology"},{"issue":"3","key":"132","first-page":"800","volume":"54","year":"1994","journal-title":"Cancer Research"},{"issue":"6","key":"133","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1097\/00000658-198012000-00012","volume":"192","year":"1980","journal-title":"Annals of Surgery"},{"key":"134","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(99)70177-7"},{"issue":"1","key":"135","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3322\/canjclin.45.1.50","volume":"45","year":"1995","journal-title":"Ca-A Cancer Journal for Clinicians"},{"issue":"3","key":"136","first-page":"926","volume":"143","year":"1993","journal-title":"American Journal of Pathology"},{"key":"137","doi-asserted-by":"publisher","DOI":"10.1038\/348555a0"},{"issue":"3-4","key":"138","first-page":"160","volume":"7","year":"1994","journal-title":"Regional Cancer Treatment"},{"issue":"4","key":"139","first-page":"977","volume":"7","year":"2001","journal-title":"Clinical Cancer Research"},{"key":"140","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5415.808"},{"issue":"15","key":"141","first-page":"3404","volume":"56","year":"1996","journal-title":"Cancer Research"},{"key":"142","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240560402"},{"issue":"3","key":"143","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1161\/01.RES.87.3.214","volume":"87","year":"2000","journal-title":"Circulation Research"},{"key":"144","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010672605265"},{"issue":"1","key":"145","first-page":"267","volume":"8","year":"2002","journal-title":"Clinical Cancer Research"},{"issue":"2","key":"146","first-page":"476","volume":"74","year":"1996","journal-title":"Laboratory Investigation"},{"issue":"2","key":"147a","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/(SICI)1097-0215(20000115)85:2<243::AID-IJC15>3.0.CO;2-2","volume":"85","year":"2000","journal-title":"International Journal of Cancer"},{"key":"147b","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2744(199912)26:4<213::AID-MC1>3.0.CO;2-Z"},{"issue":"9","key":"148","first-page":"1151","volume":"79","year":"1999","journal-title":"Laboratory Investigation"},{"issue":"4","key":"149","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1093\/ajcn\/76.4.865","volume":"76","year":"2002","journal-title":"American Journal of Clinical Nutrition"},{"issue":"5","key":"150","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/00005537-200205000-00012","volume":"112","year":"2002","journal-title":"Laryngoscope"},{"issue":"6","key":"151","first-page":"3829","volume":"21","year":"2001","journal-title":"Anticancer Research"},{"issue":"6","key":"152","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/S0093-7754(01)90026-0","volume":"28","year":"2001","journal-title":"Seminars in Oncology"},{"issue":"7","key":"153","first-page":"1793","volume":"60","year":"2000","journal-title":"Cancer Research"},{"issue":"13","key":"154","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1093\/jnci\/85.13.1038","volume":"85","year":"1993","journal-title":"Journal of the National Cancer Institute"},{"issue":"9","key":"155","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1093\/carcin\/16.9.2143","volume":"16","year":"1995","journal-title":"Carcinogenesis"},{"issue":"10","key":"156","first-page":"1889","volume":"57","year":"1997","journal-title":"Cancer Research"},{"issue":"3","key":"157","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0165-1218(89)90120-1","volume":"223","year":"1989","journal-title":"Mutation Research"},{"issue":"7","key":"158","first-page":"1943","volume":"52","year":"1992","journal-title":"Cancer Research"},{"key":"159","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(95)03993-7"},{"key":"160","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(92)90212-E"},{"issue":"1","key":"161","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1207\/s15327914nc4801_7","volume":"48","year":"2004","journal-title":"Nutrition and Cancer"},{"key":"162","doi-asserted-by":"publisher","DOI":"10.1038\/18793"},{"key":"163","doi-asserted-by":"publisher","DOI":"10.1038\/15145"},{"key":"164","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010215)91:4<822::AID-CNCR1070>3.0.CO;2-G"},{"key":"165","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.182429899"},{"key":"166","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1145"},{"key":"167","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0528"},{"issue":"4","key":"168","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3181\/00379727-220-44369","volume":"220","year":"1999","journal-title":"Proceedings of the Society for Experimental Biology and Medicine"},{"key":"169","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200310000-00007"},{"issue":"11","key":"170","first-page":"S17","volume":"6","year":"2007","journal-title":"Journal of Drugs in Dermatology"},{"issue":"3","key":"171","doi-asserted-by":"crossref","first-page":"552S","DOI":"10.1093\/jn\/132.3.552S","volume":"132","year":"2002","journal-title":"Journal of Nutrition"},{"issue":"9","key":"172","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1093\/carcin\/23.9.1467","volume":"23","year":"2002","journal-title":"Carcinogenesis"},{"issue":"1-2","key":"173","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/01635581.2001.9680615","volume":"41","year":"2001","journal-title":"Nutrition and Cancer"},{"key":"174","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/19.6.991"},{"issue":"2","key":"175","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1207\/S15327914NC352_11","volume":"35","year":"1999","journal-title":"Nutrition and Cancer"},{"key":"176","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(02)00116-4"},{"issue":"7","key":"177","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1073\/pnas.90.7.2690","volume":"90","year":"1993","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"12","key":"178","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.1016\/S0021-9258(18)45614-1","volume":"262","year":"1987","journal-title":"Journal of Biological Chemistry"},{"issue":"6","key":"179","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1093\/ajcn\/54.6.1093","volume":"54","year":"1991","journal-title":"American Journal of Clinical Nutrition"},{"issue":"3","key":"180","first-page":"790S","volume":"125","year":"1995","journal-title":"Journal of Nutrition"},{"key":"181","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.27361"},{"key":"182","volume":"5","year":"1987"},{"key":"183","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0405"},{"issue":"7","key":"184","first-page":"1857","volume":"49","year":"1989","journal-title":"Cancer Research"},{"key":"186","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1783"},{"issue":"5297","key":"187","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.275.5297.218","volume":"275","year":"1997","journal-title":"Science"},{"issue":"6","key":"188","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1093\/jn\/131.6.1844","volume":"131","year":"2001","journal-title":"Journal of Nutrition"},{"issue":"10","key":"189","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1096\/fj.01-0028fje","volume":"15","year":"2001","journal-title":"The Federation of American Societies for Experimental Biology Journal"},{"issue":"5","key":"190","first-page":"613","volume":"56","year":"2001","journal-title":"Therapie"},{"key":"191","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(01)00443-8"},{"issue":"17","key":"192","first-page":"4945","volume":"62","year":"2002","journal-title":"Cancer Research"},{"key":"193","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0410"},{"key":"194","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.018861"},{"key":"195","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22498"},{"key":"196","doi-asserted-by":"publisher","DOI":"10.1042\/BST0351377"},{"issue":"3","key":"197","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1093\/jn\/138.3.538","volume":"138","year":"2008","journal-title":"Journal of Nutrition"},{"issue":"5","key":"198","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/jnci\/94.5.391","volume":"94","year":"2002","journal-title":"Journal of the National Cancer Institute"},{"key":"199","doi-asserted-by":"publisher","DOI":"10.1080\/01635580701621338"},{"issue":"24","key":"200","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1093\/jnci\/93.24.1872","volume":"93","year":"2001","journal-title":"Journal of the National Cancer Institute"},{"key":"201","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-08-109934"},{"key":"202","first-page":"1","volume":"10","year":"2011","journal-title":"Nutrition and Cancer"},{"key":"203","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.10.063"},{"key":"204","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25208"},{"key":"205","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.29530"},{"key":"206","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23647"},{"key":"207","doi-asserted-by":"publisher","DOI":"10.3892\/or_00000589"},{"key":"208","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-006-9034-0"},{"key":"209","doi-asserted-by":"publisher","DOI":"10.1021\/jf050034w"},{"key":"210","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.80292"},{"key":"211","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9468-y"},{"key":"212","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-006-0036-4"},{"key":"213","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24830"},{"key":"214","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22790"},{"key":"215","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2010.02.004"},{"key":"216","doi-asserted-by":"publisher","DOI":"10.4149\/gpb_2010_02_134"},{"key":"217","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.08.028"},{"key":"218","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2010.05.001"},{"issue":"3","key":"219","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jnutbio.2005.06.006","volume":"17","year":"2006","journal-title":"Journal of Nutritional Biochemistry"},{"key":"221","doi-asserted-by":"publisher","DOI":"10.1021\/jf0628983"},{"issue":"3","key":"222","first-page":"536","volume":"53","year":"1993","journal-title":"Cancer Research"},{"issue":"5","key":"223","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1093\/ajcn\/84.5.1027","volume":"84","year":"2006","journal-title":"American Journal of Clinical Nutrition"},{"key":"224","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8536847"},{"key":"225","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0159"},{"key":"226","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-08-0155"},{"key":"227","doi-asserted-by":"publisher","DOI":"10.1207\/s15327914nc5401_5"},{"key":"228","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20634"},{"key":"229","doi-asserted-by":"publisher","DOI":"10.1207\/s15327914nc5401_8"},{"key":"230","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-4096"},{"issue":"3","key":"231","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/jn\/134.3.613","volume":"134","year":"2004","journal-title":"Journal of Nutrition"},{"key":"232","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8137.2004.01217.x"},{"key":"233","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2005.01.008"},{"key":"234","doi-asserted-by":"publisher","DOI":"10.1021\/jf060360r"},{"key":"235","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.3349"},{"issue":"8","key":"236","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1177\/153537020422900808","volume":"229","year":"2004","journal-title":"Experimental Biology and Medicine"},{"key":"237","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510001704"},{"issue":"5","key":"238","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1093\/ajcn\/76.5.1106","volume":"76","year":"2002","journal-title":"American Journal of Clinical Nutrition"},{"key":"239","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3181fe62e3"},{"issue":"10","key":"240","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/138.10.1939","volume":"138","year":"2008","journal-title":"Journal of Nutrition"},{"key":"241","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2008.11.001"},{"key":"242","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510168103"},{"key":"243","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp292"},{"key":"244","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2009.01.015"},{"issue":"26","key":"245","doi-asserted-by":"crossref","first-page":"7846","DOI":"10.1021\/jf0486850","volume":"52","year":"2004","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"246","doi-asserted-by":"publisher","DOI":"10.1080\/1071576021000006662"},{"key":"247","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2010.09.001"},{"key":"248","doi-asserted-by":"publisher","DOI":"10.1080\/10408390802145377"},{"key":"249","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22761"},{"key":"250","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2006.10.019"},{"key":"251","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200700317"},{"issue":"22","key":"252","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1093\/jnci\/92.22.1812","volume":"92","year":"2000","journal-title":"Journal of the National Cancer Institute"},{"issue":"3","key":"253","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/ajcn\/76.3.560","volume":"76","year":"2002","journal-title":"American Journal of Clinical Nutrition"},{"issue":"2","key":"254","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/jnci\/92.2.154","volume":"92","year":"2000","journal-title":"Journal of the National Cancer Institute"},{"key":"255","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi361"},{"key":"256","doi-asserted-by":"publisher","DOI":"10.1080\/10408390802064404"},{"key":"257","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/mnfr.200800150","volume":"53","year":"2009","journal-title":"Molecular Nutrition & Food Research"},{"key":"258","doi-asserted-by":"publisher","DOI":"10.1021\/jf071413n"},{"key":"259","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2005.01.006"},{"issue":"2","key":"260","first-page":"475","volume":"32","year":"2008","journal-title":"International Journal of Oncology"},{"key":"261","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-2290"},{"issue":"1","key":"262","first-page":"155","volume":"15","year":"2006","journal-title":"Oncology Reports"},{"key":"263","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28691"},{"key":"264","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.3.358"},{"issue":"6","key":"265","first-page":"535","volume":"11","year":"2002","journal-title":"Cancer Epidemiology Biomarkers and Prevention"},{"key":"266","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(01)00655-3"},{"key":"267","doi-asserted-by":"publisher","DOI":"10.1002\/pros.1074"},{"key":"268","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02306-9"},{"key":"269","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10183"},{"key":"270","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.14.10405"},{"issue":"4","key":"271","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/emm.2001.45","volume":"33","year":"2001","journal-title":"Experimental and Molecular Medicine"},{"issue":"4","key":"272","first-page":"305","volume":"9","year":"1998","journal-title":"Cell Growth and Differentiation"},{"issue":"4","key":"273","first-page":"2895","volume":"21","year":"2001","journal-title":"Anticancer Research"},{"key":"274","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-10-0098"},{"issue":"6","key":"275","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0022-3468(79)80271-7","volume":"14","year":"1979","journal-title":"Journal of Pediatric Surgery"},{"issue":"2","key":"276","first-page":"179","volume":"3","year":"1997","journal-title":"Clinical Cancer Research"},{"key":"277","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2009.10.007"},{"issue":"7","key":"278","first-page":"753","volume":"9","year":"2010","journal-title":"Journal of Drugs in Dermatology"},{"key":"279","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2006.10.009"},{"issue":"10","key":"280","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1093\/jn\/131.10.3161","volume":"132","year":"2002","journal-title":"Journal of Nutrition"},{"key":"281","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.05.022"},{"key":"282","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200208000-00008"},{"issue":"9","key":"283","first-page":"890","volume":"12","year":"2003","journal-title":"Cancer Epidemiology Biomarkers and Prevention"},{"key":"284","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-1018"},{"issue":"2","key":"285","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1093\/carcin\/16.2.399","volume":"16","year":"1995","journal-title":"Carcinogenesis"},{"key":"286","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1074"},{"issue":"2","key":"287","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/01635589609514473","volume":"26","year":"1996","journal-title":"Nutrition and Cancer"},{"issue":"1","key":"288","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0304-3835(95)03833-I","volume":"94","year":"1995","journal-title":"Cancer Letters"},{"key":"289","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10625"},{"key":"290","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(01)00860-7"},{"key":"291","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"292","year":"2008"},{"key":"293","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207716"},{"issue":"7","key":"294","first-page":"2024S","volume":"52","year":"1992","journal-title":"Cancer Research"},{"key":"296","doi-asserted-by":"publisher","DOI":"10.1080\/01635580701621338"}],"container-title":["Journal of Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2012\/879623.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2012\/879623.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2012\/879623.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:37Z","timestamp":1638921637000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jo\/2012\/879623\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":291,"alternative-id":["879623","879623"],"URL":"https:\/\/doi.org\/10.1155\/2012\/879623","relation":{},"ISSN":["1687-8450","1687-8469"],"issn-type":[{"value":"1687-8450","type":"print"},{"value":"1687-8469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}