{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T01:25:38Z","timestamp":1772846738319,"version":"3.50.1"},"reference-count":19,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Interdisciplinary Perspectives on Infectious Diseases"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>The pathogenesis of three different<jats:italic>Schistosoma mansoni<\/jats:italic>strains from the Brazilian states of Minas Gerais (BH strain) and S\u00e3o Paulo (SJ and SD strains) was evaluated in experimentally infected mice. Observations of the most severe clinical cases among local patients treated (SD strain) in the city of Campinas (S\u00e3o Paulo, Brazil) formed the basis of this study. Mice were used as definitive hosts and were infected with cercariae from<jats:italic>Biomphalaria tenagophila<\/jats:italic>(SJ and SD strains) and<jats:italic>Biomphalaria glabrata<\/jats:italic>(BH strains). The parameters analyzed were as follows: number of<jats:italic>S. mansoni<\/jats:italic>eggs in mice feces; number of granulomas per tissue area in liver, spleen, lungs, pancreas, and ascending colon; measurements of hepatic and intestinal granulomas; number of adult worms; and measurements of trematode eggs. The comparison among the three strains indicated that the SD strain, isolated in Campinas, presented a higher worm recovery relative to the number of penetrating cercariae. In addition, when compared to the SJ and BH strains, the SD strain demonstrated similar pathogenicity to the BH strain, with a greater quantity of granulomas in the viscera, as well as larger granulomas and eggs. Furthermore, a greater quantity of trematode eggs was also shed in the feces.<\/jats:p>","DOI":"10.1155\/2012\/894940","type":"journal-article","created":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T18:46:09Z","timestamp":1352400369000},"page":"1-7","source":"Crossref","is-referenced-by-count":6,"title":["Experimental Evaluation of the Pathogenicity of Different Strains of<i>Schistosoma mansoni<\/i>"],"prefix":"10.1155","volume":"2012","author":[{"given":"Ant\u00f4nio Aur\u00e9lio","family":"Euz\u00e9bio","sequence":"first","affiliation":[{"name":"Department of Pediatrics, School of Medical Sciences, State University of Campinas (Unicamp), Rua Tess\u00e1lia Vieira de Camargo, 126 Cidade Universit\u00e1ria Zeferino Vaz, 13083-887 Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00e1dia Regina Borim","family":"Zuim","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Institute of Biology, State University of 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