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We present an extension of the original approach to network motif detection in single, directed networks without vertex labeling to the case of a sample of directed networks with pairwise different vertex labels. A characteristic feature of this approach to network motif detection is that subnetwork counts are derived from the whole sample and the statistical tests are adjusted accordingly to assign significance to the counts. The associated computations are efficient since no simulations of random networks are involved. The motifs obtained by this approach also comprise the vertex labeling and its associated information and are characteristic of the sample. Finally, we apply this approach to describe the intricate topology of a sample of vertex-labeled networks which originate from a previous EEG study, where the processing of painful intracutaneous electrical stimuli and directed interactions within the neuromatrix of pain in patients with major depression and healthy controls was investigated. We demonstrate that the presented approach yields characteristic patterns of directed interactions while preserving their important topological information and omitting less relevant interactions.<\/jats:p>","DOI":"10.1155\/2012\/910380","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T17:05:37Z","timestamp":1337015137000},"page":"1-12","source":"Crossref","is-referenced-by-count":4,"title":["An Analytical Approach to Network Motif Detection in Samples of Networks with Pairwise Different Vertex Labels"],"prefix":"10.1155","volume":"2012","author":[{"given":"Christoph","family":"Schmidt","sequence":"first","affiliation":[{"name":"Institute of Medical Statistics, Computer Sciences and Documentation, Jena University Hospital, Friedrich Schiller University Jena, Bachstrasse 18, 07743 Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Biological and Clinical Psychology, Friedrich Schiller University Jena, Am Steiger 3, Haus 1, 07743 Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Komusiewicz","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Softwaretechnik und Theoretische Informatik, TU Berlin, Fakult\u00e4t IV, Elektrotechnik und Informatik, Sekr. 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