{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:03:38Z","timestamp":1777611818280,"version":"3.51.4"},"reference-count":61,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR19089"],"award-info":[{"award-number":["AR19089"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR051930"],"award-info":[{"award-number":["AR051930"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR19089"],"award-info":[{"award-number":["AR19089"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR051930"],"award-info":[{"award-number":["AR051930"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Herbal medicines have been used in preventing and treating skin disorders for centuries. It has been demonstrated that systemic administration of chrysanthemum extract exhibits anti-inflammatory properties. However, whether topical applications of apigenin, a constituent of chrysanthemum extract, influence cutaneous inflammation is still unclear. In the present study, we first tested whether topical applications of apigenin alleviate cutaneous inflammation in murine models of acute dermatitis. The murine models of acute allergic contact dermatitis and acute irritant contact dermatitis were established by topical application of oxazolone and phorbol 12-myristate 13-acetate (TPA), respectively. Inflammation was assessed in both dermatitis models by measuring ear thickness. Additionally, the effect of apigenin on stratum corneum function in a murine subacute allergic contact dermatitis model was assessed with an MPA5 physiology monitor. Our results demonstrate that topical applications of apigenin exhibit therapeutic effects in both acute irritant contact dermatitis and allergic contact dermatitis models. Moreover, in comparison with the vehicle treatment, topical apigenin treatment significantly reduced transepidermal water loss, lowered skin surface pH, and increased stratum corneum hydration in a subacute murine allergic contact dermatitis model. Together, these results suggest that topical application of apigenin could provide an alternative regimen for the treatment of dermatitis.<\/jats:p>","DOI":"10.1155\/2012\/912028","type":"journal-article","created":{"date-parts":[[2012,11,19]],"date-time":"2012-11-19T21:02:58Z","timestamp":1353358978000},"page":"1-7","source":"Crossref","is-referenced-by-count":31,"title":["Topical Apigenin Alleviates Cutaneous Inflammation in Murine Models"],"prefix":"10.1155","volume":"2012","author":[{"given":"Mao-Qiang","family":"Man","sequence":"first","affiliation":[{"name":"The Center for Skin Physiology Research, Dalian Skin Disease Hospital, Liaoning 116021, China"},{"name":"Dermatology Service, Veterans Affairs Medical Center and Department of Dermatology, University of California, San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Hupe","sequence":"additional","affiliation":[{"name":"Dermatology Service, Veterans Affairs Medical Center and Department of Dermatology, University of California, San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Sun","sequence":"additional","affiliation":[{"name":"Dermatology Service, Veterans Affairs Medical Center and Department of Dermatology, University of California, San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Man","sequence":"additional","affiliation":[{"name":"Dermatology Service, Veterans Affairs Medical Center and Department of Dermatology, University of California, San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodora M.","family":"Mauro","sequence":"additional","affiliation":[{"name":"Dermatology Service, Veterans Affairs Medical Center and Department of Dermatology, University of California, San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Elias","sequence":"additional","affiliation":[{"name":"Dermatology Service, Veterans Affairs Medical Center and Department of Dermatology, University of California, San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"11","key":"1","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1111\/j.1365-4632.2011.04970.x","volume":"50","year":"2011","journal-title":"International Journal of Dermatology"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.45704-0"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022188"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.30.1468"},{"issue":"10","key":"5","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4103\/0973-7847.91114","volume":"5","year":"2011","journal-title":"Pharmacognosy Reviews"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgq186"},{"issue":"6","key":"7","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.nutres.2012.04.005","volume":"32","year":"2012","journal-title":"Nutrition Research"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2010"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00690.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.11.050"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.3109\/08923971003671108"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/762918"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05471.x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1159\/000318861"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-012-1008-z"},{"issue":"12","key":"16","first-page":"1121","volume":"28","year":"2008","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"issue":"5","key":"17","first-page":"410","volume":"28","year":"2008","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.02.009"},{"key":"19","volume":"13, article 117","year":"2010","journal-title":"China Foreign Medical Treatment"},{"key":"20","first-page":"39","volume":"32","year":"2011","journal-title":"Journal of Nursing Sciences"},{"key":"21","first-page":"60","volume":"32","year":"2001","journal-title":"Jiangxi Journal of Traditional Chinese Medicine"},{"key":"22","first-page":"71","volume":"18","year":"2006","journal-title":"Natural Product Research and Development"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.4268\/cjcmm20100216"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01282-06"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20281"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2008.08.002"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3245"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22412.x"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00073.x"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701011"},{"key":"31","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1600-0625.2012.01455.x","volume":"21","year":"2012","journal-title":"Experimental Dermatology"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01205.x"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.280"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.06.049"},{"key":"35","first-page":"242","volume":"19","year":"2011","journal-title":"Acta Dermatovenerologica Croatica"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(00)00128-6"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1994.1025"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-990220"},{"issue":"1","key":"39","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0022-3565(24)29679-8","volume":"296","year":"2001","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"3","key":"40","first-page":"390","volume":"57","year":"2005","journal-title":"Pharmacological Reports"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.68.119"},{"issue":"2","key":"42","first-page":"278","volume":"147","year":"1995","journal-title":"American Journal of Pathology"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1371"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.01.034"},{"key":"45","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.jnutbio.2011.06.013","volume":"23","year":"2012","journal-title":"The Journal of Nutritional Biochemistry"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2011.02282.x"},{"issue":"2","key":"47","first-page":"104","volume":"48","year":"2001","journal-title":"Neoplasma"},{"key":"48","volume":"7, article e33805","year":"2012","journal-title":"PLoS One"},{"key":"49","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3177\/jnsv.58.161","volume":"58","year":"2012","journal-title":"Journal of Nutritional Science and Vitaminology"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.12.1161"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2005.02644.x"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb00369.x"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1080\/09546630152696107"},{"key":"54","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1248\/bpb.35.121","volume":"35","year":"2012","journal-title":"Biological and Pharmaceutical Bulletin"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.06.020"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2011.08.018"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1007\/s004180100312"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1159\/000201562"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.58674"},{"key":"60","volume":"7, article e31964","year":"2012","journal-title":"PLoS One"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2012.08.001"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2012\/912028.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2012\/912028.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2012\/912028.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T05:49:30Z","timestamp":1745214570000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ecam\/2012\/912028\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":61,"alternative-id":["912028","912028"],"URL":"https:\/\/doi.org\/10.1155\/2012\/912028","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}