{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T22:43:17Z","timestamp":1726440197938},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"European Union-FP7","award":["211713"],"award-info":[{"award-number":["211713"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Little is known about the long-term dynamics of widely interacting cortical and subcortical networks during the wake-sleep cycle. Using large-scale intracranial recordings of epileptic patients during seizure-free periods, we investigated local- and long-range synchronization between multiple brain regions over several days. For such high-dimensional data, summary information is required for understanding and modelling the underlying dynamics. Here, we suggest that a compact yet useful representation is given by a state space based on the first principal components. Using this representation, we report, with a remarkable similarity across the patients with different locations of electrode placement, that the seemingly complex patterns of brain synchrony during the wake-sleep cycle can be represented by a small number of characteristic dynamic modes. In this space, transitions between behavioral states occur through specific trajectories from one mode to another. These findings suggest that, at a coarse level of temporal resolution, the different brain states are correlated with several dominant synchrony patterns which are successively activated across wake-sleep states.<\/jats:p>","DOI":"10.1155\/2012\/912729","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T21:01:04Z","timestamp":1340917264000},"page":"1-8","source":"Crossref","is-referenced-by-count":2,"title":["Fundamental Dynamical Modes Underlying Human Brain Synchronization"],"prefix":"10.1155","volume":"2012","author":[{"given":"Catalina","family":"Alvarado-Rojas","sequence":"first","affiliation":[{"name":"Centre de Recherche de l'Institut du Cerveau et de la Moelle \u00c9pini\u00e8re (CRICM), INSERM, UMRS 975 and CNRS UMR 7225, UPMC, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, 75651 Paris cedex 13, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Le Van Quyen","sequence":"additional","affiliation":[{"name":"Centre de Recherche de l'Institut du Cerveau et de la Moelle \u00c9pini\u00e8re (CRICM), INSERM, UMRS 975 and CNRS UMR 7225, UPMC, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, 75651 Paris cedex 13, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4257(00)01090-1"},{"key":"2","first-page":"287","volume":"2","year":"1990","journal-title":"Seminars in The Neuroscience"},{"key":"3","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1146\/annurev.ne.18.030195.003011","volume":"18","year":"1995","journal-title":"Annual Review of Neuroscience"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/385157a0"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/35067550"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00353-5"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02934.x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.03.014"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3524-04.2004"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(95)93347-A"},{"issue":"4","key":"11","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/(SICI)1097-0193(1999)8:4<194::AID-HBM4>3.0.CO;2-C","volume":"8","year":"1999","journal-title":"Human Brain Mapping"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2004.10.014"},{"key":"13","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1080\/01621459.1963.10500845","volume":"58","year":"1963","journal-title":"Journal of the American Statistical Association"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/S0013-4694(98)00051-0"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e3181eaad4b"},{"year":"1968","key":"16"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.09.020"},{"issue":"3","key":"18","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.eplepsyres.2011.07.012","volume":"97","year":"2011","journal-title":"Epilepsy Research"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0437938100"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1017\/S0140525X00047336"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90489-8"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2004.04.027"}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2012\/912729.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2012\/912729.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2012\/912729.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T20:43:40Z","timestamp":1497991420000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cmmm\/2012\/912729\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":22,"alternative-id":["912729","912729"],"URL":"https:\/\/doi.org\/10.1155\/2012\/912729","relation":{},"ISSN":["1748-670X","1748-6718"],"issn-type":[{"type":"print","value":"1748-670X"},{"type":"electronic","value":"1748-6718"}],"subject":[],"published":{"date-parts":[[2012]]}}}