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The severity of mercury poisoning is consequent from the fact that it targets the thiol-containing enzymes, irreversibly oxidizing their critical thiol groups, consequently leading to an inactivation of the enzyme. The Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup>-ATPase is a sulfhydryl protein that is sensitive to Hg<jats:sup>2+<\/jats:sup>assault. On the other hand, organoseleniums are a class of pharmacologically promising compounds with potent antioxidant effects. While Hg<jats:sup>2+<\/jats:sup>oxidizes sulfhydryl groups of Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup>-ATPase under<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>conditions, the organoselenium compounds inhibit Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup>-ATPase<jats:italic>in vitro<\/jats:italic>but enhance its activities under<jats:italic>in vivo<\/jats:italic>conditions with concomitant increase in the level of endogenous thiols. Paradoxically, it appears that these two thiol oxidants can be used to counteract one another under<jats:italic>in vivo<\/jats:italic>conditions, and this hypothesis serves as the basis for this paper.<\/jats:p>","DOI":"10.1155\/2012\/924549","type":"journal-article","created":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T21:01:13Z","timestamp":1344978073000},"page":"1-12","source":"Crossref","is-referenced-by-count":12,"title":["Mercury Toxicity on Sodium Pump and Organoseleniums Intervention: A Paradox"],"prefix":"10.1155","volume":"2012","author":[{"given":"Ige Joseph","family":"Kade","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Federal University of Technology, FUTA Road, PMB 704, Akure, Ondo State, Nigeria"},{"name":"Departamento de Farmacobiolog\u00eda, Centro de Investigaci\u00f3n y de Estudios Avanzados, Sede Sur, Calzada de los Tenorios 235, Colonia Granjas Coapa, DF, 14330 M\u00e9xico, 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