{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T12:03:39Z","timestamp":1773835419252,"version":"3.50.1"},"reference-count":6,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Otolaryngology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Patients with neurofibromatosis type 1 develop both benign and malignant tumors at an increased frequency. Most of the malignant peripheral nerve sheath tumors (MPNSTs) are considered as high-grade sarcomas originating from tissues of mesenchymal origin. It is generally accepted that MPNSTs occur in about 2% to 5% of neurofibromatosis patients. In this paper, we present a 16-year-old male patient with neurofibromatosis who developed MPNST of the retromolar area. The mass enlarged rapidly in a period of 6 weeks. The patient was treated surgically, and a tumor mass with a diameter of \u2009cm was excised, but after 8 months a recurrence was observed at the same site. The sarcomatous change in a neurofibroma has an extremely poor prognosis, so patients with neurofibromatosis should be closely monitored for a possible malignancy. A rapid change in size of a preexisting neurofibroma, infiltration of the adjacent structures, intralesional hemorrhage, and pain indicate a possible malignant transformation to MPNST.<\/jats:p>","DOI":"10.1155\/2012\/936735","type":"journal-article","created":{"date-parts":[[2012,11,11]],"date-time":"2012-11-11T01:32:28Z","timestamp":1352597548000},"page":"1-3","source":"Crossref","is-referenced-by-count":8,"title":["A Case Report of a Malignant Peripheral Nerve Sheath Tumor of the Oral Cavity in Neurofibromatosis Type 1"],"prefix":"10.1155","volume":"2012","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4904-279X","authenticated-orcid":true,"given":"\u00d6zmen","family":"\u00d6zt\u00fcrk","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey"},{"name":"Kulak Burun Bogaz Anabilim Dal\u0131, Istanbul Medipol Universitesi, Kosuyolu, Kadikoy, 34718 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alper","family":"Tutkun","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Academic Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1001\/archneur.1988.00520290115023","volume":"45","year":"1988","journal-title":"Archives of Neurology"},{"issue":"5","key":"2","first-page":"1573","volume":"62","year":"2002","journal-title":"Cancer Research"},{"key":"3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3988\/jcn.2012.8.1.75","volume":"8","year":"2012","journal-title":"Journal of Clinical Neurology"},{"key":"4","first-page":"179","volume":"4","year":"2010","journal-title":"International Journal of Odontostomatology"},{"issue":"3","key":"5","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0030-4220(88)90252-6","volume":"66","year":"1988","journal-title":"Oral Surgery Oral Medicine and Oral Pathology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2008.07.004"}],"container-title":["Case Reports in Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criot\/2012\/936735.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criot\/2012\/936735.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criot\/2012\/936735.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T22:34:03Z","timestamp":1497998043000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/criot\/2012\/936735\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":6,"alternative-id":["936735","936735"],"URL":"https:\/\/doi.org\/10.1155\/2012\/936735","relation":{},"ISSN":["2090-6765","2090-6773"],"issn-type":[{"value":"2090-6765","type":"print"},{"value":"2090-6773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}