{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T22:43:26Z","timestamp":1726440206428},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Developmental Immunology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Despite the South African antiretroviral therapy rollout, which should reduce the incidence of HIV-associated tuberculosis (TB), the number of TB-attributable deaths in KwaZuluNatal (KZN) remains high. TB is often diagnosed clinically, without microbiologic confirmation, leading to inaccurate estimates of TB-attributed deaths. This may contribute to avoidable deaths, and impact population-based TB mortality estimates.<jats:italic>Objectives<\/jats:italic>. (1) To measure the number of cases with microbiologically confirmed TB in a retrospective cohort of deceased inpatients with TB-attributed hospital deaths. (2) To estimate the rates of multi-drug resistant (MDR) and extensively drug resistant (XDR) TB in this cohort.<jats:italic>Results<\/jats:italic>. Of 2752 deaths at EDH between September 2006 and March 2007, 403 (15%) were attributed to TB on the death certificate. 176 of the TB-attributed deaths (44%) had a specimen sent for smear or culture; only 64 (36%) had a TB diagnosis confirmed by either test. Of the 39 culture-confirmed cases, 27\/39 (69%) had fully susceptible TB and 27\/39 (69%) had smear-negative culture-positive TB (SNTB). Two patients had drug monoresistance, three patients had MDR-TB, and one had XDR-TB.<jats:italic>Conclusions<\/jats:italic>. Most TB-attributed deaths in this cohort were not microbiologically confirmed. Of confirmed cases, most were smear-negative, culture positive and were susceptible to all first line drugs.<\/jats:p>","DOI":"10.1155\/2012\/937013","type":"journal-article","created":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T17:02:46Z","timestamp":1332176566000},"page":"1-5","source":"Crossref","is-referenced-by-count":4,"title":["Inaccuracy of Death Certificate Diagnosis of Tuberculosis and Potential Underdiagnosis of TB in a Region of High HIV Prevalence"],"prefix":"10.1155","volume":"2012","author":[{"given":"Theresa T.","family":"Liu","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada K1H 8L6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Edendale and Grey\u2019s Hospitals, Pietermaritzburg, KwaZulu-Natal 3200, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halima","family":"Dawood","sequence":"additional","affiliation":[{"name":"Department of Medicine, Edendale and Grey\u2019s Hospitals, Pietermaritzburg, KwaZulu-Natal 3200, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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