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The major role of substance P in the onset of dental pain and inflammation is increasingly being recognised. Well-grounded experimental and clinical observations have documented an increase in substance P concentration in patients affected by caries, pulpitis, or granulomas and in those undergoing standard orthodontic or orthodontic\/dental care procedures. This paper focuses on the role of substance P in the induction and maintenance of inflammation and dental pain, in order to define future lines of research for the evaluation of therapeutic strategies aimed at modulating the complex effects of this mediator in oral tissues.<\/jats:p>","DOI":"10.1155\/2012\/951920","type":"journal-article","created":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T16:04:26Z","timestamp":1328803466000},"page":"1-6","source":"Crossref","is-referenced-by-count":67,"title":["Peripheral Mechanisms of Dental Pain: The Role of Substance P"],"prefix":"10.1155","volume":"2012","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4577-511X","authenticated-orcid":true,"given":"Paola","family":"Sacerdote","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of Milan, 20129 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Levrini","sequence":"additional","affiliation":[{"name":"Dental Clinic, 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