{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:22:11Z","timestamp":1761016931438,"version":"3.37.3"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research","doi-asserted-by":"publisher","award":["NWP0032-4"],"award-info":[{"award-number":["NWP0032-4"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Diabetes Research"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Hyperhomocysteinemia, a risk factor for cardiovascular disorder, obesity, and type 2 diabetes, is prevalent among Indians who are at high risk of these metabolic disorders. We evaluated association of common variants of genes involved in homocysteine metabolism or its levels with type 2 diabetes, obesity, and related traits in North Indians. We genotyped 90 variants in initial phase (2.115 subjects) and replicated top signals in an independent sample set (2.085 subjects). The variant<jats:italic>MTHFR<\/jats:italic>-rs1801133 was the top signal for association with type 2 diabetes (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.78<\/mml:mn><\/mml:mrow><\/mml:math>(95%\u2009\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mtext>CI<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.67<\/mml:mn><\/mml:mrow><\/mml:math>\u20130.92),<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.003<\/mml:mn><\/mml:mrow><\/mml:math>) and was also associated with 2\u2009h postload plasma glucose (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.04<\/mml:mn><\/mml:mrow><\/mml:math>), high-density lipoprotein cholesterol (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.004<\/mml:mn><\/mml:mrow><\/mml:math>), and total cholesterol (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:mrow><\/mml:math>) in control subjects. These associations were neither replicated nor significant after meta-analysis. Studies involving a larger study population and different ethnic groups are required before ruling out the role of these important candidate genes in type 2 diabetes, obesity, and related traits.<\/jats:p>","DOI":"10.1155\/2012\/960318","type":"journal-article","created":{"date-parts":[[2011,9,25]],"date-time":"2011-09-25T15:01:50Z","timestamp":1316962910000},"page":"1-7","source":"Crossref","is-referenced-by-count":15,"title":["Common Variants of Homocysteine Metabolism Pathway Genes and Risk of Type 2 Diabetes and Related Traits in Indians"],"prefix":"10.1155","volume":"2012","author":[{"given":"Ganesh","family":"Chauhan","sequence":"first","affiliation":[{"name":"Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi 110 007, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismeet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and 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