{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:39:26Z","timestamp":1740137966951,"version":"3.37.3"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["473205\/2009-2","CBB\u2014APQ-00299-08"],"award-info":[{"award-number":["473205\/2009-2","CBB\u2014APQ-00299-08"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do estado de Minas Gerais","doi-asserted-by":"crossref","award":["473205\/2009-2","CBB\u2014APQ-00299-08"],"award-info":[{"award-number":["473205\/2009-2","CBB\u2014APQ-00299-08"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute of Science and Technology in Vaccines","award":["473205\/2009-2","CBB\u2014APQ-00299-08"],"award-info":[{"award-number":["473205\/2009-2","CBB\u2014APQ-00299-08"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Developmental Immunology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>In 2010, the WHO celebrated the 30th anniversary of the smallpox eradication. Ironically, infections caused by viruses related to smallpox are being increasingly reported worldwide, including<jats:italic>Monkeypox<\/jats:italic>,<jats:italic>Cowpox,<\/jats:italic>and<jats:italic>Vaccinia virus<\/jats:italic>(VACV). Little is known about the human immunological responses elicited during acute infections caused by orthopoxviruses. We have followed VACV zoonotic outbreaks taking place in Brazil and analyzed cellular immune responses in patients acutely infected by VACV. Results indicated that these patients show a biased immune modulation when compared to noninfected controls. Amounts of B cells are low and less activated in infected patients. Although present, T CD4<jats:sup>+<\/jats:sup>cells are also less activated when compared to noninfected individuals, and so are monocytes\/macrophages. Similar results were obtained when Balb\/C mice were experimentally infected with a VACV sample isolated during the zoonotic outbreaks. Taking together, the data suggest that zoonotic VACVs modulate specific immune cell compartments during an acute infection in humans.<\/jats:p>","DOI":"10.1155\/2012\/974067","type":"journal-article","created":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T16:03:12Z","timestamp":1324396992000},"page":"1-11","source":"Crossref","is-referenced-by-count":6,"title":["Immune Modulation in Primary<i>Vaccinia virus<\/i>Zoonotic Human Infections"],"prefix":"10.1155","volume":"2012","author":[{"given":"Juliana Assis Silva","family":"Gomes","sequence":"first","affiliation":[{"name":"Departamento de Morfologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais (UFMG), Avenida Ant\u00f4nio Carlos 6627, 31270-901 Belo Horizonte, MG, Brazil"},{"name":"Instituto Ren\u00e9 Rachou (IRR), Funda\u00e7\u00e3o Oswaldo Cruz, Avenida Augusto de Lima 1715, 30190-002 Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda 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