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EBV is appealing in the pathogenesis of autoimmune disease, due to its high prevalence worldwide, its persistency throughout life in the host\u2019s B lymphocytes, and its ability to alter the host\u2019s immune response and to inhibit apoptosis. However, the evidence in support of EBV in the pathogenesis varies among diseases. Autoimmune liver diseases (AiLDs), including autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC), have a potential causative link with EBV. The data surrounding EBV and AiLD are scarce. The lack of evidence surrounding EBV in AiLD may also be reflective of the rarity of these conditions. EBV infection has also been linked to other autoimmune conditions, which are often found to be concomitant with AiLD. This paper will critically examine the literature surrounding the link between EBV infection and AiLD development. The current evidence is far from being conclusive of the theory of a link between EBV and AiLD.<\/jats:p>","DOI":"10.1155\/2012\/987471","type":"journal-article","created":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T07:14:06Z","timestamp":1338275646000},"page":"1-12","source":"Crossref","is-referenced-by-count":45,"title":["Epstein-Barr Virus as a Trigger of Autoimmune Liver Diseases"],"prefix":"10.1155","volume":"2012","author":[{"given":"Eirini I.","family":"Rigopoulou","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Thessaly Medical School, Viopolis, 41110 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Smyk","sequence":"additional","affiliation":[{"name":"Institute of Liver Studies and Liver Unit, King\u2019s College London School of Medicine, King\u2019s College Hospital, Denmark Hill Campus, London SE5 9RS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire 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