{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:34:16Z","timestamp":1770485656684,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T00:00:00Z","timestamp":1369267200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Fundaci\u00f3n Sociedad Espa\u00f1ola de Alergolog\u00eda e Inmunolog\u00eda Cl\u00ednica"},{"DOI":"10.13039\/100008061","name":"Fundaci\u00f3n Mutua Madrile\u00f1a","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Allergy"],"published-print":{"date-parts":[[2013,5,23]]},"abstract":"<jats:p>Gastroallergic anisakiasis (GAA) and <jats:italic>Anisakis<\/jats:italic>-sensitization-associated chronic urticaria (CU+) differ with respect to specific IgE levels. We hypothesised different immunoglobulin avidities in both entities as well as their dependence on TI and fish consumption. 16 patients with GAA and 17 patients with CU+ were included, and immunoglobulin levels were analysed by CAP (Phadia). IgE and IgG avidity indexes (AvIgE and AvIgG, resp.) were also determined. IgG avidity was higher in GAA than in CU+ (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.035<\/mml:mn><\/mml:math>), whereas there was a tendency to lower IgE avidity in GAA (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.095<\/mml:mn><\/mml:math>). When analysing all patients, AvIgG was positively correlated with specific IgE, IgG, and IgG<jats:sub>4<\/jats:sub> as well as total IgE (Rho between 0.66 and 0.71;  <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:math>), but AvIgE was negatively correlated with specific IgE (Rho \u22120.57; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), specific IgG<jats:sub>4<\/jats:sub> (Rho \u22120.38; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>), and total IgE (Rho 0.66; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). In GAA, weekly fish consumption was positively associated with AvIgE (Rho 0.51; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). A multivariate regression showed that time interval was the main explaining factor for AvIgE in GAA. We could show a differential behaviour of immunoglobulin isotype avidities in both entities and their dependence on fish-eating habits as well as on the time elapsed to the last parasitic episode.<\/jats:p>","DOI":"10.1155\/2013\/106781","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T21:00:56Z","timestamp":1369342856000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["Avidity Studies in <i>Anisakis simplex<\/i>-Associated Allergic Diseases"],"prefix":"10.1155","volume":"2013","author":[{"given":"Carmen","family":"Cu\u00e9llar","sequence":"first","affiliation":[{"name":"Departamento de Parasitolog\u00eda, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Valls","sequence":"additional","affiliation":[{"name":"Servicio de Alergia, Instituto de Investigaci\u00f3n Sanitaria, Hospital Universitario de la Princesa, C\/Diego de Le\u00f3n 62, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Consolaci\u00f3n","family":"de Frutos","sequence":"additional","affiliation":[{"name":"Servicio de Alergia, Instituto de Investigaci\u00f3n Sanitaria, Hospital Universitario de la Princesa, C\/Diego de Le\u00f3n 62, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Rodero","sequence":"additional","affiliation":[{"name":"Departamento de Parasitolog\u00eda, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7725-981X","authenticated-orcid":true,"given":"Alvaro","family":"Daschner","sequence":"additional","affiliation":[{"name":"Servicio de Alergia, Instituto de Investigaci\u00f3n Sanitaria, Hospital Universitario de la Princesa, C\/Diego de Le\u00f3n 62, 28006 Madrid, 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