{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T04:07:46Z","timestamp":1784002066829,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Alzheimer's Disease"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Cardiovascular risk factors influence onset and progression of Alzheimer\u2019s disease. Among cognitively healthy people, changes in brain structure and function associated with high blood pressure, diabetes, or other vascular risks suggest differential regional susceptibility to neuronal damage. In patients with Alzheimer\u2019s disease, hippocampal and medial temporal lobe atrophy indicate early neuronal loss preferentially in key areas for learning and memory. We wanted to investigate whether this regional cortical thinning would be modulated by cardiovascular risk factors. We utilized high-resolution magnetic resonance imaging and a cortical unfolding technique to determine the cortical thickness of medial temporal subregions in 30 patients with Alzheimer\u2019s disease. Cardiovascular risk was assessed using a sex-specific multivariable risk score. Greater cardiovascular risk was associated with cortical thinning in the hippocampus CA2\/3\/dentate gyrus area but not other hippocampal and medial temporal subregions. APOE genotype, a family history of Alzheimer\u2019s disease, and age did not influence cortical thickness. Alzheimer\u2019s disease-related atrophy could mask the influence of genetic risk factors or age on regional cortical thickness in medial temporal lobe regions, whereas the impact of vascular risk factors remains detectable. This highlights the importance of cardiovascular disease prevention and treatment in patients with Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.1155\/2013\/108021","type":"journal-article","created":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T18:01:24Z","timestamp":1382378484000},"page":"1-7","source":"Crossref","is-referenced-by-count":3,"title":["Cardiovascular Risk and Hippocampal Thickness in Alzheimer\u2019s Disease"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8947-0428","authenticated-orcid":true,"given":"Markus","family":"Donix","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Division of Old Age Psychiatry and Cognitive Neuropsychiatry, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, 01307 Dresden, Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), 01307 Dresden, 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