{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:46:00Z","timestamp":1786715160885,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To establish the prevalence of bronchiectasis in asthma in relation to patients\u2019 oral corticosteroid requirements and to explore whether the increased risk is due to blood immunoglobulin (Ig) concentration.<jats:italic>Methods<\/jats:italic>. Case-control cross-sectional study, including 100 sex- and age-matched patients, 50 with non-steroid-dependent asthma (NSDA) and 50 with steroid-dependent asthma (SDA). Study protocol: (a) measurement of Ig and gG subclass concentration; (b) forced spirometry; and (c) high-resolution thoracic computed tomography. When bronchiectasis was detected, a specific etiological protocol was applied to establish its etiology.<jats:italic>Results<\/jats:italic>. The overall prevalence of bronchiectasis was 12\/50 in the SDA group and 6\/50 in the NSDA group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mtext>n<\/mml:mtext><mml:mtext>s<\/mml:mtext><\/mml:mrow><\/mml:math>). The etiology was documented in six patients (four NSDA and two SDA). After excluding these patients, the prevalence of bronchiectasis was 20% (10\/50) in the SDA group and 2\/50 (4%) in the NSDA group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>). Patients with asthma-associated bronchiectasis presented lower FEV<jats:sub>1<\/jats:sub>values than patients without bronchiectasis, but the levels of Ig and subclasses of IgG did not present differences.<jats:italic>Conclusions<\/jats:italic>. Steroid-dependent asthma seems to be associated with a greater risk of developing bronchiectasis than non-steroid-dependent asthma. This is probably due to the disease itself rather than to other influencing factors such as immunoglobulin levels.<\/jats:p>","DOI":"10.1155\/2013\/109219","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T16:20:04Z","timestamp":1384359604000},"page":"1-7","source":"Crossref","is-referenced-by-count":36,"title":["Prevalence of Bronchiectasis in Asthma according to Oral Steroid Requirement: Influence of Immunoglobulin Levels"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9033-7712","authenticated-orcid":true,"given":"Manel","family":"Luj\u00e1n","sequence":"first","affiliation":[{"name":"Servei de Pneumologia, Hospital de Sabadell, Corporaci\u00f3 Sanit\u00e0ria i Universit\u00e0ria Parc Taul\u00ed, Parc Taul\u00ed 1, Sabadell, 08208 Barcelona, Spain"},{"name":"Departament de Medicina, Universitat Aut\u00f2noma de Barcelona (UAB), Campus de la UAB, Cerdanyola del Vall\u00e8s, 08193 Barcelona, 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