{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:55:33Z","timestamp":1788872133242,"version":"build-2803163510"},"reference-count":109,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Galderma do Brasil Ltda."},{"name":"Ortol\u00e2ndia\/SP, Brazil"},{"name":"Arese Pharma Ltda."},{"name":"Valinhos\/SP, Brazil"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology Research and Practice"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Acne is a dermatosis that involves an altered sebum pattern.\n                    <jats:italic>Objectives<\/jats:italic>\n                    . (1) To evaluate if a treatment based on antibiotics (lymecycline) can alter fatty acids contents of the sebum of patients with acne; (2) to evaluate if oral supplementation of fatty acids can interfere with fatty acids contents of the sebum of patients with acne; (3) to evaluate if there is any interaction in fatty acids contents of the sebum of patients with acne when they use both antibiotics and oral supplementation of fatty acids.\n                    <jats:italic>Methods<\/jats:italic>\n                    . Forty-five male volunteers with inflammatory acne vulgaris were treated with 300\u2009mg of lymecycline per day, with 540\u2009mg of\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mrow>\n                        <mml:mi>\u03b3<\/mml:mi>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    -linolenic acid, 1,200\u2009mg of linoleic acid, and 510\u2009mg of oleic acid per day, or with both regimens for 90 days. Every 30 days, a sample of sebum from the forehead was collected for fatty acids\u2019 chromatographic analysis.\n                    <jats:italic>Results<\/jats:italic>\n                    . Twelve fatty acids studied exhibited some kind of pattern changes during the study: C12:0, C14:0, C15:0, C16:1, C18:0, C18:1n9c+C18:1n9t, C18:2n6t, C18:3n6, C18:3n3, C20:1, C22:0, and C24:0.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . The daily administration of lymecycline and\/or specific fatty acids may slightly influence some fatty acids levels present in the sebum of patients with inflammatory acne vulgaris.\n                  <\/jats:p>","DOI":"10.1155\/2013\/120475","type":"journal-article","created":{"date-parts":[[2013,9,26]],"date-time":"2013-09-26T17:09:52Z","timestamp":1380215392000},"page":"1-14","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and\/or Oral Fatty Acid Supplementation"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0873-6840","authenticated-orcid":true,"given":"Adilson","family":"Costa","sequence":"first","affiliation":[{"name":"Service of Dermatology of the Pontifical Catholic University of Campinas, Campinas, SP, Brazil"},{"name":"KOLderma Clinical Trials 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