{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:48:44Z","timestamp":1788871724687,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC100-2314-B-303-013"],"award-info":[{"award-number":["NSC100-2314-B-303-013"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["TCIRP 98004-02"],"award-info":[{"award-number":["TCIRP 98004-02"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009383","name":"Tzu Chi University","doi-asserted-by":"publisher","award":["NSC100-2314-B-303-013"],"award-info":[{"award-number":["NSC100-2314-B-303-013"]}],"id":[{"id":"10.13039\/100009383","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009383","name":"Tzu Chi University","doi-asserted-by":"publisher","award":["TCIRP 98004-02"],"award-info":[{"award-number":["TCIRP 98004-02"]}],"id":[{"id":"10.13039\/100009383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>\n                    Hemorrhagic shock (HS) following acute alcohol intoxication can increase proinflammatory cytokine production and induce marked immunosuppression. We investigated the effects of ethanol on physiopathology and cytokine levels following HS in acutely alcohol-intoxicated rats. Rats received an intravenous injection of 5\u2009g\/kg ethanol over 3\u2009h followed by HS induced by withdrawal of 40% of total blood volume from a femoral arterial catheter over 30\u2009min. Mean arterial pressure (MAP) and heart rate (HR) were monitored continuously for 48\u2009h after the start of blood withdrawal. Biochemical parameters, including hemoglobin, ethanol, glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), blood urea nitrogen (BUN), creatinine (Cre), lactic dehydrogenase (LDH), and creatine phosphokinase (CPK), were measured at 30\u2009min before induction of HS and 0, 1, 3, 6, 9, 12, 18, 24, and 48\u2009h after HS. Serum tumor necrosis factor-\n                    <jats:italic>\u03b1<\/jats:italic>\n                    (TNF-\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ) and interleukin-6 (IL-6) levels were measured at 1 and 12\u2009h after HS. The liver, kidneys, and lungs were removed for pathology at 48\u2009h later. HS significantly increased HR, blood GOT, GPT, BUN, Cre, LDH, CPK, TNF-\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , and IL-6 levels and decreased hemoglobin and MAP in rats. Acute ethanol intoxication further increased serum levels of GOT, GPT, BUN, Cre, LDH, CPK, TNF-\n                    <jats:italic>\u03b1<\/jats:italic>\n                    and IL-6 elevation following HS. Acutely intoxicated rats exacerbated the histopathologic changes in the liver, kidneys, and lungs following HS.\n                  <\/jats:p>","DOI":"10.1155\/2013\/121786","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T17:02:03Z","timestamp":1379005323000},"page":"1-9","source":"Crossref","is-referenced-by-count":11,"title":["Heavy Ethanol Intoxication Increases Proinflammatory Cytokines and Aggravates Hemorrhagic Shock-Induced Organ Damage in Rats"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1752-8130","authenticated-orcid":true,"given":"Tsung-Ming","family":"Hu","sequence":"first","affiliation":[{"name":"Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan"},{"name":"Department of Psychiatry, Yuli Veterans Hospital, Hualien, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru-Ping","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nursing, Tzu Chi University, Hualien, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Jen","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nursing, Tzu Chi College of Technology, Hualien, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Maun","family":"Subeq","sequence":"additional","affiliation":[{"name":"Department of Nursing, Tzu Chi University, Hualien, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nien-Tsung","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Immunology and Molecular Medicine, Tzu Chi University, Hualien, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9364-4558","authenticated-orcid":true,"given":"Bang-Gee","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Tzu Chi General Hospital, Hualien, Taiwan"},{"name":"School of 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