{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:22:17Z","timestamp":1789939337895,"version":"4.0.1"},"reference-count":18,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Ministry of Health, Malaysia","award":["JPP-IMR 09-035"],"award-info":[{"award-number":["JPP-IMR 09-035"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Microbiology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Acute melioidosis may present as localised or septicaemic infections and can be fatal if left untreated.<jats:italic>Burkholderia pseudomallei<\/jats:italic>resistant to antibiotics used for the treatment of melioidosis had been reported. The aim of this study was to determine the in vitro antibiotic susceptibility patterns of<jats:italic>Burkholderia pseudomallei<\/jats:italic>isolated in Malaysia to a panel of antibiotics used for the treatment of melioidosis and also to potential alternative antibiotics such as tigecycline, ampicillin\/sulbactam, and piperacillin\/tazobactam. A total of 170<jats:italic>Burkholderia pseudomallei<\/jats:italic>isolates were subjected to minimum inhibitory concentration determination using<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>E<\/mml:mi><\/mml:mrow><\/mml:math>-test method to eleven antibiotics. All isolates were sensitive to meropenem and piperacillin\/tazobactam. For ceftazidime, imipenem, amoxicillin\/clavulanic acid, and doxycycline resistance was observed in 1 isolate (0.6%) for each of the antibiotics. Trimethoprim\/sulfamethoxazole resistance was observed in 17 (10%) isolates. For other antibiotics, ampicillin\/sulbactam, chloramphenicol, tigecycline, and ciprofloxacin resistance were observed in 1 (0.6%), 6 (3.5%), 60 (35.3%) and 98 (57.7%) isolates respectively. One isolate B170\/06 exhibited resistance to 4 antibiotics, namely, ciprofloxacin, chloramphenicol, trimethoprim\/sulfamethoxazole, and tigecycline. In conclusion, the Malaysian isolates were highly susceptible to the current antibiotics used in the treatment of melioidosis in Malaysia. Multiple resistances to the antibiotics used in the maintenance therapy are the cause for a concern.<\/jats:p>","DOI":"10.1155\/2013\/121845","type":"journal-article","created":{"date-parts":[[2013,9,26]],"date-time":"2013-09-26T21:09:09Z","timestamp":1380229749000},"page":"1-7","source":"Crossref","is-referenced-by-count":31,"title":["The In Vitro Antibiotic Susceptibility of Malaysian Isolates of<i>Burkholderia pseudomallei<\/i>"],"prefix":"10.1155","volume":"2013","author":[{"given":"Norazah","family":"Ahmad","sequence":"first","affiliation":[{"name":"Bacteriology Unit, Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohaidah","family":"Hashim","sequence":"additional","affiliation":[{"name":"Bacteriology Unit, Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azura","family":"Mohd Noor","sequence":"additional","affiliation":[{"name":"Bacteriology Unit, Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"issue":"5","key":"1","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1093\/infdis\/159.5.890","volume":"159","year":"1989","journal-title":"Journal of Infectious Diseases"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2004.01269.x"},{"key":"3","year":"2008"},{"issue":"12","key":"4","doi-asserted-by":"crossref","first-page":"945","DOI":"10.47102\/annals-acadmedsg.V39N12p945","volume":"39","year":"2010","journal-title":"Annals of the Academy of Medicine Singapore"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05517-11"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1080\/00365540701402988"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2010.02.005"},{"issue":"5","key":"8","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1365-2672.1997.tb02867.x","volume":"82","year":"1997","journal-title":"Journal of Applied Microbiology"},{"key":"9","volume":"30"},{"key":"10","volume":"32","year":"2012"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(00)00334-4"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S35529"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki151"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.10.4020-4025.2005"},{"issue":"1-2","key":"15","first-page":"24","volume":"64","year":"2001","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(97)90044-4"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.4.1555-1557.2006"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.07.022"}],"container-title":["International Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijmicro\/2013\/121845.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijmicro\/2013\/121845.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijmicro\/2013\/121845.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T05:12:47Z","timestamp":1716009167000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ijmicro\/2013\/121845\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":18,"alternative-id":["121845","121845"],"URL":"https:\/\/doi.org\/10.1155\/2013\/121845","relation":{},"ISSN":["1687-918X","1687-9198"],"issn-type":[{"value":"1687-918X","type":"print"},{"value":"1687-9198","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}