{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T18:36:30Z","timestamp":1793903790123,"version":"4.8.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Receptor for Advanced Glycation End-products (RAGE) is a multi-ligand receptor ubiquitous present on epithelial, neuronal, vascular and inflammatory cells, usually expressed at low levels in homeostasis and to increased degrees at sites of stress or injury. The aim of the present study was to evaluate sRAGE plasma levels in patients with Acute Coronary Syndrome (ACS) and to assess its diagnostic efficacy in identification of patients with acute events. Plasma levels of sRAGE were determined in 860 patients with Coronary Artery Disease (CAD): 530 patients presented stable angina and 330 were observed during acute ischemic event (147 with unstable angina and 183 with myocardial infarction). sRAGE plasma levels were significantly lower in patients with ACS than in patients with stable angina: [median 584\u2009pg\/mL (IQR: 266\u2013851\u2009pg\/mL) in MI patients, median 769\u2009pg\/mL (IQR: 394\u2013987\u2009pg\/mL) in patients with unstable angina, median 834\u2009pg\/mL (IQR 630\u20131005\u2009pg\/mL) in patients with stable angina;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>]. sRAGE levels did not differ among ACS patients stratified by the extent of coronary artery disease. In conclusion, this study confirm the role of sRAGE in activation and progression of inflammatory process and suggests the possibility that sRAGE can be considered an indicator of destabilization of vulnerable plaque.<\/jats:p>","DOI":"10.1155\/2013\/129360","type":"journal-article","created":{"date-parts":[[2013,8,18]],"date-time":"2013-08-18T17:00:35Z","timestamp":1376845235000},"page":"135-140","source":"Crossref","is-referenced-by-count":32,"title":["Plasma Levels of Soluble Receptor for Advanced Glycation End Products and Coronary Atherosclerosis: Possible Correlation with Clinical Presentation"],"prefix":"10.1155","volume":"35","author":[{"given":"Colomba","family":"Falcone","sequence":"first","affiliation":[{"name":"Department of Cardiology, \u201cIstituti Clinici di Pavia e Vigevano\u201d University Hospital, Via Parco Vecchio 27, 27100 Pavia, Italy"},{"name":"Interdepartmental Center for Research in Molecular Medicine (CIRMC), University of Pavia, Via Taramelli 24, 27100 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