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The afferent visual pathway (AVP) is frequently involved in MS, such that one in every five individuals affected presents with acute optic neuritis (ON).  As a functionally eloquent system, the AVP is amenable to interrogation with highly reliable and reproducible tests that can be used to define a structural-functional paradigm of CNS injury. The AVP has numerous unique advantages as a clinical model of MS. In this review, the parameters and merits of the AVP model are highlighted.  Moreover, the roles the AVP model may play in elucidating mechanisms of brain injury and repair in MS are described.<\/jats:p>","DOI":"10.1155\/2013\/134858","type":"journal-article","created":{"date-parts":[[2013,10,23]],"date-time":"2013-10-23T22:28:59Z","timestamp":1382567339000},"page":"1-17","source":"Crossref","is-referenced-by-count":73,"title":["The Afferent Visual Pathway: Designing a Structural-Functional Paradigm of Multiple Sclerosis"],"prefix":"10.1155","volume":"2013","author":[{"given":"Fiona","family":"Costello","sequence":"first","affiliation":[{"name":"Departments of Clinical Neurosciences and Surgery (Ophthalmology), Hotchkiss Brain Institute, University of Calgary, 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