{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:29:07Z","timestamp":1740169747411,"version":"3.37.3"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Four-drug regimens, such as FIr-B\/FOx schedule, can improve efficacy of first-line treatment of metastatic colorectal cancer (MCRC) patients. The present study specifically evaluates feasibility of FIr-B\/FOx first-line intensive regimen in fit young-elderly MCRC patients, representing approximately 40% of overall MCRC patients. Activity, efficacy, and safety were equivalent to overall MCRC patients, not significantly different according to<jats:italic>KRAS<\/jats:italic>genotype. Clinical outcome was significantly prolonged in liver-limited compared to other\/multiple metastatic disease. Safety evaluation of the individual young-elderly patient showed that limiting toxicity syndromes (LTS) in multiple sites were significantly increased, compared to LTS in single site, with respect to non-elderly patients.<\/jats:p>","DOI":"10.1155\/2013\/143273","type":"journal-article","created":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T16:05:56Z","timestamp":1383753956000},"page":"1-9","source":"Crossref","is-referenced-by-count":12,"title":["Effectiveness and Safety of Intensive Triplet Chemotherapy Plus Bevacizumab, FIr-B\/FOx, in Young-Elderly Metastatic Colorectal Cancer Patients"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8407-2479","authenticated-orcid":true,"given":"Gemma","family":"Bruera","sequence":"first","affiliation":[{"name":"Medical Oncology, S. Salvatore Hospital, University of L'Aquila, 67100 L'Aquila, Italy"},{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila, 67100 L'Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia","family":"Cannita","sequence":"additional","affiliation":[{"name":"Medical Oncology, S. Salvatore Hospital, University of L'Aquila, 67100 L'Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo Victor","family":"Giordano","sequence":"additional","affiliation":[{"name":"Radiology, S. Salvatore Hospital, 67100 L'Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Vicentini","sequence":"additional","affiliation":[{"name":"Hepatobiliar-Pancreatic Surgery, S. Salvatore Hospital, 67100 L'Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Ficorella","sequence":"additional","affiliation":[{"name":"Medical Oncology, S. Salvatore Hospital, University of L'Aquila, 67100 L'Aquila, Italy"},{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila, 67100 L'Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Ricevuto","sequence":"additional","affiliation":[{"name":"Medical Oncology, S. Salvatore Hospital, University of L'Aquila, 67100 L'Aquila, Italy"},{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila, 67100 L'Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"doi-asserted-by":"publisher","key":"1","DOI":"10.1186\/1471-2407-10-567"},{"doi-asserted-by":"publisher","key":"2","DOI":"10.1517\/14712598.2011.582462"},{"issue":"2","key":"3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.clcc.2011.11.002","volume":"11","year":"2012","journal-title":"Clinical Colorectal Cancer"},{"issue":"4","key":"4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.clcc.2012.05.001","volume":"11","year":"2012","journal-title":"Clinical Colorectal Cancer"},{"issue":"1, article 135","key":"5","volume":"10","year":"2012","journal-title":"BMC Medicine"},{"key":"43"},{"doi-asserted-by":"publisher","key":"6","DOI":"10.1093\/jnci\/djq456"},{"key":"7","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1093\/annonc\/mds236","volume":"23","year":"2012","journal-title":"Annals of Oncology"},{"doi-asserted-by":"publisher","key":"8","DOI":"10.1016\/j.ctrv.2009.10.008"},{"doi-asserted-by":"publisher","key":"9","DOI":"10.1093\/annonc\/mdn532"},{"issue":"12","key":"10","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/nrgastro.2012.196","volume":"9","year":"2012","journal-title":"Nature Reviews Gastroenterology & Hepatology"},{"issue":"4","key":"11","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1200\/JCO.1998.16.4.1582","volume":"16","year":"1998","journal-title":"Journal of Clinical Oncology"},{"doi-asserted-by":"publisher","key":"12","DOI":"10.1093\/annonc\/mdh344"},{"issue":"8","key":"13","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1200\/JCO.1999.17.8.2412","volume":"17","year":"1999","journal-title":"Journal of Clinical Oncology"},{"doi-asserted-by":"publisher","key":"14","DOI":"10.1007\/s002800050826"},{"doi-asserted-by":"publisher","key":"15","DOI":"10.1200\/JCO.2007.14.0509"},{"doi-asserted-by":"publisher","key":"16","DOI":"10.1093\/annonc\/mdh267"},{"doi-asserted-by":"publisher","key":"17","DOI":"10.1200\/JCO.2006.06.9039"},{"doi-asserted-by":"publisher","key":"18","DOI":"10.1002\/cncr.23091"},{"doi-asserted-by":"publisher","key":"19","DOI":"10.1016\/S0140-6736(11)60399-1"},{"doi-asserted-by":"publisher","key":"20","DOI":"10.1056\/NEJMoa032691"},{"doi-asserted-by":"publisher","key":"21","DOI":"10.1200\/JCO.2008.17.7931"},{"doi-asserted-by":"publisher","key":"22","DOI":"10.1007\/s00432-009-0712-3"},{"doi-asserted-by":"publisher","key":"23","DOI":"10.1159\/000320222"},{"doi-asserted-by":"publisher","key":"24","DOI":"10.1093\/annonc\/mdp233"},{"volume":"27","year":"2009","journal-title":"Journal of Clinical Oncology","key":"25"},{"doi-asserted-by":"publisher","key":"26","DOI":"10.1200\/JCO.2009.27.4860"},{"doi-asserted-by":"publisher","key":"27","DOI":"10.1038\/sj.bjc.6603011"},{"doi-asserted-by":"publisher","key":"28","DOI":"10.1016\/j.critrevonc.2009.08.003"},{"issue":"5","key":"29","first-page":"1345","volume":"15","year":"2006","journal-title":"Oncology Reports"},{"doi-asserted-by":"publisher","key":"30","DOI":"10.3892\/or-00000805"},{"doi-asserted-by":"publisher","key":"31","DOI":"10.1038\/sj.bjc.6603685"},{"doi-asserted-by":"publisher","key":"32","DOI":"10.1038\/modpathol.2011.60"},{"key":"33","first-page":"690","volume":"58","year":"1963","journal-title":"Journal of the American Statistical Association"},{"issue":"3","key":"34","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/jnci\/92.3.205","volume":"92","year":"2000","journal-title":"Journal of the National Cancer Institute"},{"key":"35","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","volume":"53","year":"1958","journal-title":"Journal of the American Statistical Association"},{"key":"36","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2307\/2344317","volume":"135","year":"1972","journal-title":"Journal of the Royal Statistical Society A"},{"doi-asserted-by":"publisher","key":"37","DOI":"10.1016\/S1470-2045(10)70175-3"},{"doi-asserted-by":"publisher","key":"38","DOI":"10.1038\/sj.bjc.6605940"},{"doi-asserted-by":"publisher","key":"39","DOI":"10.1200\/JCO.2008.20.2879"},{"doi-asserted-by":"publisher","key":"40","DOI":"10.1002\/bjs.6889"},{"doi-asserted-by":"publisher","key":"41","DOI":"10.1007\/s12094-007-0072-x"},{"doi-asserted-by":"publisher","key":"42","DOI":"10.1093\/jnci\/djn126"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/143273.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/143273.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/143273.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T21:31:27Z","timestamp":1498080687000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2013\/143273\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":43,"alternative-id":["143273","143273"],"URL":"https:\/\/doi.org\/10.1155\/2013\/143273","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2013]]}}}