{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:40:40Z","timestamp":1790538040771,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"V\u00e4sterbotten County Council (ALF)"},{"name":"Medical Faculty of Ume\u00e5 University"},{"name":"=Swedish Medical Research Council"},{"name":"=Parkinson Foundation in Sweden"},{"name":"King Gustaf V\u2019s and Queen Victoria\u2019s Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>We prospectively evaluated the diagnostic contribution of<jats:sup>123<\/jats:sup>I-FP-Cit (DAT) and<jats:sup>123<\/jats:sup>I-IBZM (IBZM) SPECT in 29 patients with Parkinson's disease (PD) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn>74.4<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>4.2<\/mml:mn><\/mml:math>years) and 28 patients with atypical parkinsonian diseases (APD) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn>74.3<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>9.2<\/mml:mn><\/mml:math>years). Twelve had multiple system atrophy (MSA) and 16 progressive supranuclear palsy (PSP). Sixteen age-matched healthy controls (HC) were included. DAT and IBZM SPECTs were made at baseline and after 1 year in all PD patients and in 20 (DAT) and 18 (IBZM) of the APD patients, and after 3 years in 22 (DAT) and 17 (IBZM) of the PD patients and in 10 (DAT) and 10 (IBZM) of the APD patients. The relative DAT uptake decrease was faster in PD and PSP than in HC and MSA. In PSP the DAT uptake was lower than in MSA after 1 year but not after 3 years. Baseline IBZM uptake was not significantly different between patients and HC or between PD and APD. One year after initiated dopaminergic treatment the mean IBZM uptake in the MSA patients remained high compared to PSP and after 3 years compared to PD, PSP, and HC. Thus, the pattern of uptake of these ligands over time may be of value in discriminating between these diagnoses.<\/jats:p>","DOI":"10.1155\/2013\/143532","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T20:40:55Z","timestamp":1379623255000},"page":"1-14","source":"Crossref","is-referenced-by-count":15,"title":["Pre- and Postsynaptic Dopamine SPECT in Idiopathic Parkinsonian Diseases: A Follow-Up Study"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8169-2584","authenticated-orcid":true,"given":"Susanna","family":"Jakobson Mo","sequence":"first","affiliation":[{"name":"Department of Radiation Sciences, Diagnostic Radiology, Ume\u00e5 University, 90187 Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Linder","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Neuroscience, Neurology, Ume\u00e5 University, 90187 Ume\u00e5, 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