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In North America, the role of treatment for heart problems dates back to 1800. Currently, evidence is accumulating from various in vivo and in vitro studies that hawthorn extracts exert a wide range of cardiovascular pharmacological properties, including antioxidant activity, positive inotropic effect, anti-inflammatory effect, anticardiac remodeling effect, antiplatelet aggregation effect, vasodilating effect, endothelial protective effect, reduction of smooth muscle cell migration and proliferation, protective effect against ischemia\/reperfusion injury, antiarrhythmic effect, lipid-lowering effect and decrease of arterial blood pressure effect. On the other hand, reviews of placebo-controlled trials have reported both subjective and objective improvement in patients with mild forms of heart failure (NYHA I\u2013III), hypertension, and hyperlipidemia. This paper discussed the underlying pharmacology mechanisms in potential cardioprotective effects and elucidated the clinical applications of<jats:italic>Crataegus<\/jats:italic>and its various extracts.<\/jats:p>","DOI":"10.1155\/2013\/149363","type":"journal-article","created":{"date-parts":[[2013,12,29]],"date-time":"2013-12-29T21:31:31Z","timestamp":1388352691000},"page":"1-16","source":"Crossref","is-referenced-by-count":88,"title":["Effect of<i>Crataegus<\/i>Usage in Cardiovascular Disease Prevention: An Evidence-Based Approach"],"prefix":"10.1155","volume":"2013","author":[{"given":"Jie","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingjiang","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical 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