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Due to the hydrophobic nature of both of these classes of molecules, they present challenges for use in immunological assays and have therefore been somewhat neglected in studies of T-cell reactivity in MS compared to more soluble molecules such as the myelin basic proteins and the extracellular domain of myelin oligodendrocyte glycoprotein. This review firstly looks at the makeup of CNS myelin, with an emphasis on proteolipids and glycolipids. Next, a retrospective of what is known of T-cell reactivity directed against proteolipids and glycolipids in patients with MS is presented, and the implications of the findings are discussed. Finally, this review considers the question of what would be required to prove a definite role for autoreactivity against proteolipids and glycolipids in the pathogenesis of MS.<\/jats:p>","DOI":"10.1155\/2013\/151427","type":"journal-article","created":{"date-parts":[[2013,11,7]],"date-time":"2013-11-07T21:01:43Z","timestamp":1383858103000},"page":"1-16","source":"Crossref","is-referenced-by-count":20,"title":["Autoimmune T-Cell Reactivity to Myelin Proteolipids and Glycolipids in Multiple Sclerosis"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4440-4309","authenticated-orcid":true,"given":"Judith M.","family":"Greer","sequence":"first","affiliation":[{"name":"UQ Centre for Clinical Research, Royal Brisbane & Women\u2019s Hospital, The University of Queensland, Brisbane, QLD 4029, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","volume-title":"Diffraction studies of molecular 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