{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T14:08:30Z","timestamp":1769522910952,"version":"3.49.0"},"reference-count":59,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. The anti-inflammatory proteins annexin-A1 and galectin-1 have been associated with tumor progression. This scenario prompted us to investigate the relationship between the gene and protein expression of annexin-A1 (<jats:italic>ANXA1<\/jats:italic>\/AnxA1) and galectin-1 (<jats:italic>LGALS1<\/jats:italic>\/Gal-1) in an inflammatory gastric lesion as chronic gastritis (CG) and gastric adenocarcinoma (GA) and its association with<jats:italic>H. pylori<\/jats:italic>infection.<jats:italic>Methods<\/jats:italic>. We analyzed 40 samples of CG, 20 of GA, and 10 of normal mucosa (C) by the quantitative real-time PCR (qPCR) technique and the immunohistochemistry assay.<jats:italic>Results<\/jats:italic>. High<jats:italic>ANXA1<\/jats:italic>mRNA expression levels were observed in 90% (36\/40) of CG cases (mean relative quantification RQ\u2009=\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mn>4.26\u2009<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>\u20092.03<\/mml:mn><\/mml:mrow><\/mml:math>) and in 80% (16\/20) of GA cases (mean RQ\u2009=\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mn>4.38\u2009<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>\u20094.77<\/mml:mn><\/mml:mrow><\/mml:math>). However,<jats:italic>LGALS1<\/jats:italic>mRNA levels were high (mean RQ\u2009=\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mn>2.44\u2009<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>\u20093.26<\/mml:mn><\/mml:mrow><\/mml:math>) in 60% (12\/20) of the GA cases, while low expression was found in CG (mean RQ\u2009=\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mn>0.43<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>3.13<\/mml:mn><\/mml:mrow><\/mml:math>;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:mrow><\/mml:math>). Normal mucosa showed modest immunoreactivity in stroma but not in epithelium, while stroma and epithelium displayed an intense immunostaining in CG and GA for both proteins.<jats:italic>Conclusion<\/jats:italic>. These results have provided evidence that galectin-1 and mainly annexin-A1 are overexpressed in both gastritis and gastric cancer, suggesting a strong association of these proteins with chronic gastric inflammation and carcinogenesis.<\/jats:p>","DOI":"10.1155\/2013\/152860","type":"journal-article","created":{"date-parts":[[2013,1,31]],"date-time":"2013-01-31T16:00:43Z","timestamp":1359648043000},"page":"1-11","source":"Crossref","is-referenced-by-count":32,"title":["Expression of Annexin-A1 and Galectin-1 Anti-Inflammatory Proteins and mRNA in Chronic Gastritis and Gastric Cancer"],"prefix":"10.1155","volume":"2013","author":[{"given":"Yvana Cristina","family":"Jorge","sequence":"first","affiliation":[{"name":"Department of Biology, S\u00e3o Paulo State University (UNESP), Campus de S\u00e3o Jos\u00e9 do Rio Preto, Rua Crist\u00f3v\u00e3o Colombo 2265, 15054-000 S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayra Mioto","family":"Mataruco","sequence":"additional","affiliation":[{"name":"Department of Biology, S\u00e3o Paulo State University (UNESP), Campus de S\u00e3o Jos\u00e9 do Rio Preto, Rua Crist\u00f3v\u00e3o Colombo 2265, 15054-000 S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro Pires","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Department of Biology, S\u00e3o Paulo State University (UNESP), Campus de S\u00e3o Jos\u00e9 do Rio Preto, Rua Crist\u00f3v\u00e3o Colombo 2265, 15054-000 S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Fl\u00e1via Teixeira","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Biology, S\u00e3o Paulo State University (UNESP), Campus de S\u00e3o Jos\u00e9 do Rio Preto, Rua Crist\u00f3v\u00e3o Colombo 2265, 15054-000 S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Garcia","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Biology, S\u00e3o Paulo State University (UNESP), Campus de S\u00e3o Jos\u00e9 do Rio Preto, Rua Crist\u00f3v\u00e3o Colombo 2265, 15054-000 S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina Curado","family":"Valsechi","sequence":"additional","affiliation":[{"name":"Department of Biology, S\u00e3o Paulo State University (UNESP), Campus de S\u00e3o Jos\u00e9 do Rio Preto, Rua Crist\u00f3v\u00e3o Colombo 2265, 15054-000 S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaor","family":"Caetano","sequence":"additional","affiliation":[{"name":"Rio Preto Endoscopy Center, S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Endoscopy Service, Hospital de Base, S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9lia Sebastiana de Jesus","family":"Fazzio","sequence":"additional","affiliation":[{"name":"Legal Medicine Department and Pathology Service, Hospital de Base, S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Alberto","family":"Thom\u00e9","sequence":"additional","affiliation":[{"name":"Institute of Anatomical Pathology and Cytopathology, S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Rahal","sequence":"additional","affiliation":[{"name":"Department of Biology, S\u00e3o Paulo State University (UNESP), Campus de S\u00e3o Jos\u00e9 do Rio Preto, Rua Crist\u00f3v\u00e3o Colombo 2265, 15054-000 S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia Maria","family":"Oliani","sequence":"additional","affiliation":[{"name":"Department of Biology, S\u00e3o Paulo State University (UNESP), Campus de S\u00e3o Jos\u00e9 do Rio Preto, Rua Crist\u00f3v\u00e3o Colombo 2265, 15054-000 S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Elizabete","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Biology, S\u00e3o Paulo State University (UNESP), Campus de S\u00e3o Jos\u00e9 do Rio Preto, Rua Crist\u00f3v\u00e3o Colombo 2265, 15054-000 S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1053\/j.gastro.2012.07.009","volume":"143","year":"2012","journal-title":"Gastroenterology"},{"issue":"13","key":"2","first-page":"3554","volume":"48","year":"1988","journal-title":"Cancer Research"},{"key":"3","first-page":"787","volume-title":"Stomach","year":"2005"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.2008\/003160-0"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.08.033"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41929_7.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2008.09.005"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1023\/B:GLYC.0000014088.21242.e0"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080342"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-003-1235-z"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1661"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M409752200"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602493"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-005-0059-4"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(03)00051-7"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1021\/pr060212g"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-010-9248-8"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00531.2007"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-008-9178-y"},{"issue":"1","key":"20","first-page":"57","volume":"15","year":"2006","journal-title":"Oncology Reports"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1002\/ar.21176"},{"key":"22","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/apm.1965.64.1.31","volume":"64","year":"1965","journal-title":"Acta Pathologica et Microbiologica Scandinavica"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"issue":"12","key":"24","first-page":"3155","volume":"60","year":"2000","journal-title":"Cancer Research"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1590\/S1413-86702006000400008"},{"issue":"1","key":"26","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/nrc703","volume":"2","year":"2002","journal-title":"Nature Reviews Cancer"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02570.x"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2010007500143"},{"issue":"9, article e45","key":"29","volume":"29","year":"2001","journal-title":"Nucleic Acids Research"},{"key":"30","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.gene.2012.03.038","volume":"500","year":"2012","journal-title":"Gene"},{"issue":"1","key":"31","first-page":"117","volume":"8","year":"2002","journal-title":"Clinical Cancer Research"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2010.05.017"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22639"},{"key":"34","doi-asserted-by":"crossref","first-page":"262","DOI":"10.4048\/jbc.2011.14.4.262","volume":"14","year":"2011","journal-title":"Journal Breast of Cancer"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.222.243"},{"key":"36","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.kjms.2011.10.004","volume":"28","year":"2012","journal-title":"Kaohsiung Journal of Medical Sciences"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-011-9380-1"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20992"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27565"},{"key":"40","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/j.1365-2559.2008.03186.x","volume":"53","year":"2008","journal-title":"Histopathology"},{"issue":"4","key":"41","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3748\/wjg.v9.i4.645","volume":"9","year":"2003","journal-title":"World Journal of Gastroenterology"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2006.06.008"},{"key":"43","first-page":"389","volume":"59","year":"2012","journal-title":"Hepatogastroenterology"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-327346"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2008.02973.x"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1516-7"},{"issue":"4","key":"47","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1074\/mcp.M200008-MCP200","volume":"1","year":"2002","journal-title":"Molecular & Cellular Proteomics"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2003-4-9-117"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7270.2008.00418.x"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-9-90"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi008"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-08-0147"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00054-05"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208155200"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900664"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021155"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-011-0044-2"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1002\/prca.200780088"},{"key":"59","doi-asserted-by":"crossref","first-page":"10176","DOI":"10.3390\/ijms130810176","volume":"13","year":"2012","journal-title":"International Journal of Molecular Sciences"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2013\/152860.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2013\/152860.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2013\/152860.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T23:13:01Z","timestamp":1562627581000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/mi\/2013\/152860\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":59,"alternative-id":["152860","152860"],"URL":"https:\/\/doi.org\/10.1155\/2013\/152860","relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}