{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:17:58Z","timestamp":1791332278417,"version":"4.3.1"},"reference-count":127,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100013382","name":"Institute of Translational Health Sciences","doi-asserted-by":"crossref","award":["UL1RR025014"],"award-info":[{"award-number":["UL1RR025014"]}],"id":[{"id":"10.13039\/100013382","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100013382","name":"Institute of Translational Health Sciences","doi-asserted-by":"crossref","award":["P20RR015583"],"award-info":[{"award-number":["P20RR015583"]}],"id":[{"id":"10.13039\/100013382","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100013382","name":"Institute of Translational Health Sciences","doi-asserted-by":"crossref","award":["UL1RR025014"],"award-info":[{"award-number":["UL1RR025014"]}],"id":[{"id":"10.13039\/100013382","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100013382","name":"Institute of Translational Health Sciences","doi-asserted-by":"crossref","award":["P20RR015583"],"award-info":[{"award-number":["P20RR015583"]}],"id":[{"id":"10.13039\/100013382","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Caribbean Research Exchange Grants Program","award":["UL1RR025014"],"award-info":[{"award-number":["UL1RR025014"]}]},{"name":"Caribbean Research Exchange Grants Program","award":["P20RR015583"],"award-info":[{"award-number":["P20RR015583"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Chronic exposure to particulate matter air pollution is known to cause inflammation leading to respiratory- and cardiovascular-related sickness and death. Mexico City Metropolitan Area children exhibit an early brain imbalance in genes involved in oxidative stress, inflammation, and innate and adaptive immune responses. Early dysregulated neuroinflammation, brain microvascular damage, production of potent vasoconstrictors, and perturbations in the integrity of the neurovascular unit likely contribute to progressive neurodegenerative processes. The accumulation of misfolded proteins coincides with the anatomical distribution observed in the early stages of both Alzheimer\u2019s and Parkinson's diseases. We contend misfolding of hyperphosphorylated tau (HP<jats:italic>\u03c0<\/jats:italic>), alpha-synuclein, and beta-amyloid could represent a compensatory early protective response to the sustained systemic and brain inflammation. However, we favor the view that the chronic systemic and brain dysregulated inflammation and the diffuse vascular damage contribute to the establishment of neurodegenerative processes with childhood clinical manifestations. Friend turns Foe early; therefore, implementation of neuroprotective measures to ameliorate or stop the inflammatory and neurodegenerative processes is warranted in exposed children. Epidemiological, cognitive, structural, and functional neuroimaging and mechanistic studies into the association between air pollution exposures and the development of neuroinflammation and neurodegeneration in children are of pressing importance for public health.<\/jats:p>","DOI":"10.1155\/2013\/161687","type":"journal-article","created":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T21:03:56Z","timestamp":1360271036000},"page":"1-16","source":"Crossref","is-referenced-by-count":88,"title":["Early Alzheimer\u2019s and Parkinson\u2019s Disease Pathology in Urban Children: Friend versus Foe Responses\u2014It Is Time to Face the Evidence"],"prefix":"10.1155","volume":"2013","author":[{"given":"Lilian","family":"Calder\u00f3n-Garcidue\u00f1as","sequence":"first","affiliation":[{"name":"Center for Structural and Functional Neurosciences, The University of Montana, 32 Campus Drive, Skaggs Building 287, Missoula, MT 59812, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maricela","family":"Franco-Lira","sequence":"additional","affiliation":[{"name":"Departamento de Investigaci\u00f3n, Hospital Central Militar, Secretaria de la Defensa Nacional, 11649 M\u00e9xico, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonieta","family":"Mora-Tiscare\u00f1o","sequence":"additional","affiliation":[{"name":"Departamentos de Radiolog\u00eda y Patolog\u00eda Experimental, Instituto Nacional de Pediatria, 04530 M\u00e9xico, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto","family":"Medina-Cortina","sequence":"additional","affiliation":[{"name":"Departamentos de Radiolog\u00eda y Patolog\u00eda Experimental, Instituto Nacional de Pediatria, 04530 M\u00e9xico, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Torres-Jard\u00f3n","sequence":"additional","affiliation":[{"name":"Centro de Ciencias de la Atm\u00f3sfera, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510 M\u00e9xico, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kavanaugh","sequence":"additional","affiliation":[{"name":"Center for Structural and Functional Neurosciences, The University of Montana, 32 Campus Drive, Skaggs Building 287, Missoula, MT 59812, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1319.006"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s12199-007-0018-5"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1176064"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209290"},{"key":"5","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2217\/fnl.12.27","volume":"7","year":"2012","journal-title":"Future Neurology"},{"key":"6","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s12640-012-9331-x","volume":"22","year":"2012","journal-title":"Neurotoxicity Research"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25032"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2009.05.009"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2009.GR02"},{"key":"10","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1161\/CIR.0b013e3181dbece1","volume":"121","year":"2010","journal-title":"Circulation"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.237560"},{"issue":"10","key":"12","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.5194\/acp-7-2447-2007","volume":"7","year":"2007","journal-title":"Atmospheric Chemistry and Physics"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.5194\/acp-10-8697-2010"},{"key":"14","first-page":"103","volume-title":"Health benefits of air pollution control","year":"2002"},{"issue":"1","key":"15","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1080\/00139157.1996.9930972","volume":"38","year":"1996","journal-title":"Environment"},{"key":"16","series-title":"Ecological Studies","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/978-0-387-22520-3_6","volume-title":"Air pollution levels and trends in the M\u00e9xico City metropolitan area","volume":"156","year":"2002"},{"issue":"10","key":"17","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1289\/ehp.5913","volume":"111","year":"2003","journal-title":"Environmental Health Perspectives"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2006.10.078"},{"key":"19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.5194\/acp-8-111-2008","volume":"8","year":"2008","journal-title":"Atmospheric Chemistry and Physics"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-011-0647-5"},{"issue":"1\u20133","key":"22","first-page":"10","volume":"291","year":"2012","journal-title":"Toxicology"},{"key":"23","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/EDE.0b013e318276ccb8","volume":"24","year":"2013","journal-title":"Epidemiology"},{"issue":"8","key":"24","doi-asserted-by":"crossref","first-page":"975","DOI":"10.2105\/AJPH.78.8.975","volume":"78","year":"1988","journal-title":"American Journal of Public Health"},{"key":"25","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.scitotenv.2012.05.002","volume":"430","year":"2012","journal-title":"Science of the Total Environment"},{"key":"26","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1289\/ehp.9641","volume":"115","year":"2007","journal-title":"Environmental Health Perspectives"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10338"},{"key":"28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1177\/0192623308329340","volume":"37","year":"2009","journal-title":"Toxicologic Pathology"},{"key":"29","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.bandc.2008.04.008","volume":"68","year":"2008","journal-title":"Brain and Cognition"},{"key":"30","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3233\/JAD-2011-110722","volume":"28","year":"2012","journal-title":"Journal of Alzheimer Disease"},{"key":"31"},{"issue":"1","key":"32","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3233\/JAD-2012-120610","volume":"31","year":"2012","journal-title":"Journal of Alzheimer's Disease"},{"key":"33","volume":"3, article 217","year":"2012","journal-title":"Frontiers in Psychology"},{"issue":"1","key":"34","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1046\/j.1525-1373.2000.22304.x","volume":"223","year":"2000","journal-title":"Proceedings of the Society for Experimental Biology and Medicine"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1177\/0192623307313011"},{"key":"36","volume":"3, article 46","year":"2012","journal-title":"Frontiers in Psychology"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(02)00180-8"},{"issue":"4","key":"38","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1165\/ajrcmb.19.4.3176","volume":"19","year":"1998","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"39","doi-asserted-by":"crossref","first-page":"6858","DOI":"10.1016\/j.biomaterials.2012.06.016","volume":"33","year":"2012","journal-title":"Biomaterials"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1038\/nature08100"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1126\/science.1156995"},{"key":"42","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00005-011-0155-9","volume":"60","year":"2012","journal-title":"Archivum Immunologiae Et Therapiae Experimentalis"},{"key":"43","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1293\/tox.25.163","volume":"25","year":"2012","journal-title":"Journal of Toxicologic Pathology"},{"key":"44","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.bandc.2011.09.006","volume":"77","year":"2011","journal-title":"Brain Cognition"},{"key":"45","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1080\/01926230252929954","volume":"30","year":"2002","journal-title":"Toxicologic Pathology"},{"key":"46","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1080\/01926230309789","volume":"31","year":"2003","journal-title":"Toxicologic Pathology"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.3109\/13506129.2011.570385"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2010.11.004"},{"issue":"4","key":"49","doi-asserted-by":"crossref","first-page":"685","DOI":"10.3233\/JAD-2008-15413","volume":"15","year":"2008","journal-title":"Journal of Alzheimer's Disease"},{"issue":"8","key":"50","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1166\/jnn.2009.GR07","volume":"9","year":"2009","journal-title":"Journal of Nanoscience and Nanotechnology"},{"key":"51","volume":"8, article 105","year":"2011","journal-title":"Journal of Neuroinflammation"},{"key":"52","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1289\/ehp.1002986","volume":"119","year":"2011","journal-title":"Environmental Health Perspectives"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1038\/nri2565"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200410250-00001"},{"issue":"1","key":"55","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1096\/fj.03-0364fje","volume":"18","year":"2004","journal-title":"The FASEB Journal"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1038\/nrn752"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.050215"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1021\/nn103530b"},{"key":"59","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/187152712799960817","volume":"11","year":"2012","journal-title":"CNS & Neurological Disorders"},{"key":"60","doi-asserted-by":"crossref","first-page":"835","DOI":"10.2217\/nnm.11.154","volume":"7","year":"2012","journal-title":"Nanomedicine"},{"key":"61","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.3390\/ijms12096267","volume":"12","year":"2011","journal-title":"International Journal of Molecular Sciences"},{"issue":"5","key":"62","volume":"7","year":"2012","journal-title":"PLoS One"},{"key":"63","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.neuro.2011.12.001","volume":"33","year":"2012","journal-title":"Neurotoxicology"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20467"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-106997"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2007.12.004"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2011.03.007"},{"issue":"6","key":"68","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1600-0773.1996.tb00021.x","volume":"79","year":"1996","journal-title":"Pharmacology and Toxicology"},{"issue":"2-3","key":"69","first-page":"181","volume":"20","year":"1999","journal-title":"NeuroToxicology"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfj206"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2011.05.001"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.03926.x"},{"key":"73","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrneurol.2012.80","volume":"8","year":"2012","journal-title":"Nature Reviews Neurology"},{"key":"74","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.nbd.2011.10.026","volume":"46","year":"2012","journal-title":"Neurobiology of Disease"},{"key":"75","volume":"12, article 24","year":"2012","journal-title":"BMC Neurology"},{"key":"76","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.brainres.2011.12.030","volume":"1442","year":"2012","journal-title":"Brain Research"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2009.02.117"},{"issue":"3","key":"78","volume":"2","year":"2012","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"key":"79","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00701-012-1292-6","volume":"154","year":"2012","journal-title":"Acta Neurochirurgica"},{"key":"80","volume":"11, article 36","year":"2012","journal-title":"Cardiovascular Diabetology"},{"issue":"13","key":"81","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1016\/j.jprot.2012.05.011","volume":"75","year":"2012","journal-title":"Journal of Proteomics"},{"issue":"12","key":"82","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.imbio.2012.07.020","volume":"217","year":"2012","journal-title":"Immunobiology"},{"key":"83","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev-cellbio-101011-155745","volume":"28","year":"2012","journal-title":"Annual Review of Cell and Developmental Biology"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200940168"},{"key":"85","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.it.2012.03.001","volume":"33","year":"2012","journal-title":"Trends in Immunology"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2009.12.004"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1177\/1091581810383587"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20533"},{"issue":"4","key":"89","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","volume":"82","year":"1991","journal-title":"Acta Neuropathologica"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00065-9"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-002-0808-2"},{"issue":"11","key":"92","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1097\/NEN.0b013e318232a379","volume":"70","year":"2011","journal-title":"Journal of Neuropathology & Experimental Neurology"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0789-4"},{"key":"94","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1749-6632.1991.tb00218.x","volume":"640","year":"1991","journal-title":"Annals of the New York Academy of Sciences"},{"key":"95","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1111\/j.1582-4934.2011.01507.x","volume":"16","year":"2012","journal-title":"Journal of Cellular and Molecular Medicine"},{"issue":"11","key":"96","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.neurol.2012.07.004","volume":"168","year":"2012","journal-title":"Revue Neurologique"},{"key":"97","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1212\/01.wnl.0000257815.20548.df","volume":"68","year":"2007","journal-title":"Neurology"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.1159\/000328864"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181a187c6"},{"key":"100","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.21"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181ad53fd"},{"key":"102","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2008.11.006"},{"key":"103","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.280"},{"key":"104","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.204685"},{"key":"105","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013567"},{"key":"106","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c3400"},{"key":"107","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.609768"},{"key":"108"},{"key":"109","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/578373"},{"issue":"6","key":"110","doi-asserted-by":"crossref","first-page":"639","DOI":"10.2174\/156720511796717131","volume":"8","year":"2011","journal-title":"Current Alzheimer Research"},{"key":"111","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2005.02.008"},{"key":"112","doi-asserted-by":"publisher","DOI":"10.1038\/nature08890"},{"key":"113","doi-asserted-by":"publisher","DOI":"10.1042\/BST0380967"},{"key":"114","volume":"4, article 49","year":"2010","journal-title":"Frontiers in Neuroscience"},{"key":"115","doi-asserted-by":"publisher","DOI":"10.1042\/BST0381016"},{"key":"116","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.expneurol.2012.08.028","volume":"238","year":"2012","journal-title":"Experimental Neurology"},{"issue":"9","key":"117","volume":"7","year":"2012","journal-title":"PLOS ONE"},{"key":"118"},{"key":"119","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-175976"},{"key":"120"},{"key":"121","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/j.freeradbiomed.2012.08.569","volume":"53","year":"2012","journal-title":"Free Radical Biology & Medicine"},{"key":"122"},{"key":"123"},{"key":"124","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S1474-4422(12)70191-6","volume":"11","year":"2012","journal-title":"Lancet Neurology"},{"key":"125"},{"key":"126","first-page":"599","volume":"8","year":"2012","journal-title":"Journal of Vascular Health and Risk Management"},{"key":"127","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/biof.200","volume":"38","year":"2012","journal-title":"Biofactors"},{"issue":"8","key":"128","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.arcmed.2012.09.009","volume":"43","year":"2012","journal-title":"Archives of Medical Research"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/161687.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/161687.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/161687.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T07:55:56Z","timestamp":1588838156000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2013\/161687\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":127,"alternative-id":["161687","161687"],"URL":"https:\/\/doi.org\/10.1155\/2013\/161687","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}