{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T17:46:31Z","timestamp":1784223991385,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100005283","name":"Funda\u00e7\u00e3o Cearense de Apoio ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007355","name":"State University of Cear\u00e1","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007355","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009051","name":"Universidad T\u00e9cnica Federico Santa Mar\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009051","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Knowledge of medicinal plants is often the only therapeutic resource of many communities and ethnic groups. \u201cErva-baleeira\u201d,<jats:italic>Cordia verbenacea<\/jats:italic>DC<jats:italic>.<\/jats:italic>, is one of the species of plants currently exploited for the purpose of producing a phytotherapeutic product extracted from its leaves. In Brazil, its major distribution is in the region of the Atlantic Forest and similar vegetation. The crude extract is utilized in popular cultures in the form of hydroalcoholic, decoctions and infusions, mainly as antimicrobial, antiinflammatory and analgesic agents. The aim of the present study was to establish a chemical and comparative profile of the experimental antibacterial activity and resistance modifying activity with ethnopharmacological reports. Phytochemical prospecting and HPLC analysis of the extract and fractions were in agreement with the literature with regard to the presence of secondary metabolites (tannins and flavonoids). The extract and fraction tested did not show clinically relevant antibacterial activity, but a synergistic effect was observed when combined with antibiotic, potentiating the antibacterial effect of aminoglycosides. We conclude that tests of antibacterial activity and modulating the resistance presented in this work results confirm the ethnobotanical and ethnopharmacological information, serving as a parameter in the search for new alternatives for the treatment of diseases.<\/jats:p>","DOI":"10.1155\/2013\/164215","type":"journal-article","created":{"date-parts":[[2013,6,2]],"date-time":"2013-06-02T21:01:05Z","timestamp":1370206865000},"page":"1-7","source":"Crossref","is-referenced-by-count":38,"title":["Biological Activities and Chemical Characterization of<i>Cordia verbenacea<\/i>DC. as Tool to Validate the Ethnobiological Usage"],"prefix":"10.1155","volume":"2013","author":[{"given":"Edinardo Fagner Ferreira","family":"Matias","sequence":"first","affiliation":[{"name":"Universidade Estadual do Cear\u00e1-UECE-60740-000, Fortaleza, CE, Brazil"},{"name":"Rede Nordeste de Biotecnologia-RENORBIO-60740-000, Fortaleza, CE, Brazil"},{"name":"Faculdade Le\u00e3o Sampaio-CE-FALS-63180-000, Juazeiro do Norte, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriv\u00e2nia Ferreira","family":"Alves","sequence":"additional","affiliation":[{"name":"Faculdade Le\u00e3o Sampaio-CE-FALS-63180-000, Juazeiro do Norte, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Sousa","family":"Santos","sequence":"additional","affiliation":[{"name":"Faculdade Le\u00e3o Sampaio-CE-FALS-63180-000, Juazeiro do Norte, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celestina Elba","family":"Sobral de Souza","sequence":"additional","affiliation":[{"name":"Universidade Regional do Cariri-URCA-63.100-000, Crato, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Victor de","family":"Alencar Ferreira","sequence":"additional","affiliation":[{"name":"Universidade Regional do Cariri-URCA-63.100-000, Crato, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Karyzia Lima","family":"Santos de Lavor","sequence":"additional","affiliation":[{"name":"Universidade Regional do Cariri-URCA-63.100-000, Crato, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Gomes","family":"Figueredo","sequence":"additional","affiliation":[{"name":"Universidade Regional do Cariri-URCA-63.100-000, Crato, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciene","family":"Ferreira de Lima","sequence":"additional","affiliation":[{"name":"Universidade Regional do Cariri-URCA-63.100-000, Crato, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Ant\u00f4nio","family":"Vieira dos Santos","sequence":"additional","affiliation":[{"name":"Faculdade Le\u00e3o Sampaio-CE-FALS-63180-000, Juazeiro do Norte, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00f3rido Sampaio","family":"Neves Peixoto","sequence":"additional","affiliation":[{"name":"Faculdade Le\u00e3o Sampaio-CE-FALS-63180-000, Juazeiro do Norte, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arac\u00e9lio","family":"Viana Colares","sequence":"additional","affiliation":[{"name":"Rede Nordeste de Biotecnologia-RENORBIO-60740-000, Fortaleza, CE, Brazil"},{"name":"Faculdade Le\u00e3o Sampaio-CE-FALS-63180-000, Juazeiro do Norte, CE, Brazil"},{"name":"Universidade Federal do Maranh\u00e3o-UFMA-65085-580, S\u00e3o Lu\u00eds, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Augusti Boligon","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria-UFSM-97105-900, Santa Maria, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rog\u00e9rio de Aquino","family":"Saraiva","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria-UFSM-97105-900, Santa Maria, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margareth Linde","family":"Athayde","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria-UFSM-97105-900, Santa Maria, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Batista Teixeira","family":"da Rocha","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria-UFSM-97105-900, Santa Maria, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irwin Rose","family":"Alencar Menezes","sequence":"additional","affiliation":[{"name":"Universidade Regional do Cariri-URCA-63.100-000, Crato, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique","family":"Douglas Melo Coutinho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Microbiologia e Biologia Molecular, Departamento de Qu\u00edmica Biol\u00f3gica, Universidade Regional do Cariri-URCA, Crato-CE, Brasil. 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