{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T15:50:32Z","timestamp":1740153032016,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. The interaction between vitamin D deficiency and primary hyperparathyroidism (PHPT) is not fully understood. The aim of this study was to investigate whether patients with PHPT from Spain and Sweden differed in vitamin D status and PHPT disease activity before and after surgery.<jats:italic>Methods<\/jats:italic>. We compared two cohorts of postmenopausal women from Spain<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>126<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>and Sweden<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>128<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>that had first-time surgery for sporadic, uniglandular PHPT. Biochemical variables reflecting bone metabolism and disease activity, including levels of 25-hydroxy vitamin D<jats:sub>3<\/jats:sub>(25(OH)D) and bone mineral density, BMD, were measured pre- and one year postoperatively.<jats:italic>Results<\/jats:italic>. Median preoperative 25(OH)D levels were lower, and adenoma weight, PTH, and urinary calcium levels were higher in the Spanish cohort. The Spanish patients had higher preoperative levels of PTH (13.5 versus 11.0\u2009pmol\/L,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), urinary calcium (7.3 versus 4.1\u2009mmol\/L,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), and heavier adenomas (620 versus 500\u2009g,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). The mean increase in BMD was higher in patients from Spain and in patients with vitamin D deficiency one year after surgery.<jats:italic>Conclusion<\/jats:italic>. Postmenopasual women with PHPT from Spain had a more advanced disease and lower vitamin 25(OH)D levels. Improvement in bone density one year after surgery was higher in patients with preoperative vitamin D deficiency.<\/jats:p>","DOI":"10.1155\/2013\/164939","type":"journal-article","created":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T17:21:34Z","timestamp":1375723294000},"page":"1-6","source":"Crossref","is-referenced-by-count":4,"title":["Vitamin D Status in Patients Operated for Primary Hyperparathyroidism: Comparison of Patients from Southern and Northern Europe"],"prefix":"10.1155","volume":"2013","author":[{"given":"Erik","family":"Nordenstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Surgery, Lund University Hospital, 221 85 Lund, Sweden"},{"name":"Departement of Clinical Sciences, Lund University, Sweden"},{"name":"Department of Surgery, Skane University Hospital, Lund University, S-221 85 Lund, 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