{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:51:50Z","timestamp":1760298710152},"reference-count":17,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Hospital de Carabineros de Chile Research Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Oncology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Developments in immunological and quantitative real-time PCR-based analysis have enabled the detection, enumeration, and characterization of circulating tumor cells (CTCs). It is assumed that the detection of CTCs is associated with cancer, based on the finding that CTCs can be detected in all major cancer and not in healthy subjects or those with benign disease.<jats:italic>Methods and Patients<\/jats:italic>. Consecutive men, with suspicion of prostate cancer, had blood samples taken before prostate biopsy; mononuclear cells were obtained using differential gel centrifugation and CPCs detecting using anti-PSA immunocytochemistry. Positive samples underwent further classification with anti-P504S.<jats:italic>Results<\/jats:italic>. 329 men underwent prostate biopsy; of these men 83 underwent a second biopsy and 44 a third one. Of those with a biopsy negative for cancer, 19\/226 (8.4%) had CPCs PSA (+) P504S (\u2212) detected at first biopsy, 6\/74 (8.1%) at second biopsy, and 5\/33 (15.2%) at third biopsy. Men with cancer-positive biopsies did not have PSA (+) P504S (\u2212) CPCs detected. These benign cells were associated with chronic prostatitis.<jats:italic>Conclusions<\/jats:italic>. Patients with chronic prostatitis may have circulating prostate cells detected in blood, which do not express the enzyme P504S and should be thought of as benign in nature.<\/jats:p>","DOI":"10.1155\/2013\/165014","type":"journal-article","created":{"date-parts":[[2013,4,17]],"date-time":"2013-04-17T17:01:19Z","timestamp":1366218079000},"page":"1-5","source":"Crossref","is-referenced-by-count":16,"title":["Circulating Prostate Cells Found in Men with Benign Prostate Disease Are P504S Negative: Clinical Implications"],"prefix":"10.1155","volume":"2013","author":[{"given":"Nigel P.","family":"Murray","sequence":"first","affiliation":[{"name":"Division of Medicine, Hospital Carabineros of Chile, Sim\u00f3n Bol\u00edvar 2200, \u00d1u\u00f1oa, 7770199 Santiago, Chile"},{"name":"Instituto de BioOncolog\u00eda, Avenida Salvador 95, Oficina 95, Providencia, 7500710 Santiago, Chile"},{"name":"Circulating Tumor Cell Unit, Faculty of Medicine Universidad Mayor, Renato S\u00e1nchez 4369, Las Condes, 7550224 Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Reyes","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad Diego Portales, Manuel Rodriguez Sur 415, 8370179 Santiago, Chile"},{"name":"Urology Service, Hospital Carabineros of Chile, Sim\u00f3n Bol\u00edvar 2200, \u00d1u\u00f1oa, 7770199 Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Bad\u00ednez","sequence":"additional","affiliation":[{"name":"Radiotherapy, Fundaci\u00f3n Arturo L\u00f3pez P\u00e9rez, Rancagua 899, Providencia, 7500921 Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson","family":"Orellana","sequence":"additional","affiliation":[{"name":"Urology Service, Hospital Carabineros of Chile, Sim\u00f3n Bol\u00edvar 2200, \u00d1u\u00f1oa, 7770199 Santiago, 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