{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T10:19:09Z","timestamp":1752229149600,"version":"3.37.3"},"reference-count":63,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parkinson's Disease"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>In 1961, David C. Poskanzer and Robert S. Schwab presented a paper, \u201cStudies in the epidemiology of Parkinson\u2019s disease predicting its disappearance as a major clinical entity by 1980.\u201d This paper introduced the hypothesis that Parkinson\u2019s disease was derived from a single aetiology, the influenza virus. We review the original Poskanzer and Schwab hypothesis that Parkinson\u2019s disease was based on the association between the 1918-19 influenza epidemic and the later observation of Parkinsonism in some influenza sufferers. We also further explore the prediction that Parkinson\u2019s disease would totally disappear as an entity once original influenza victims were all deceased. Current research has revealed that there are many potential causes and factors important in the occurrence of Parkinson\u2019s disease, postencephalitic Parkinsonism, and encephalitis lethargica. Poskanzer and Schwab presented a novel hypothesis; however, it was proven false by a combination of research and time.<\/jats:p>","DOI":"10.1155\/2013\/167843","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T17:01:11Z","timestamp":1370970071000},"page":"1-7","source":"Crossref","is-referenced-by-count":6,"title":["The Demise of Poskanzer and Schwab\u2019s Influenza Theory on the Pathogenesis of Parkinson\u2019s Disease"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9323-8311","authenticated-orcid":true,"given":"Danny","family":"Estupinan","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, 3450 Hull Road, 4th Floor, Gainesville, FL 32607, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1182-0779","authenticated-orcid":true,"given":"Sunina","family":"Nathoo","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, 3450 Hull Road, 4th Floor, Gainesville, FL 32607, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Okun","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, 3450 Hull Road, 4th Floor, Gainesville, FL 32607, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"year":"1817","key":"1"},{"issue":"1","key":"2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/mds.870010104","volume":"1","year":"1986","journal-title":"Movement Disorders"},{"issue":"1","key":"3","volume":"1","year":"2011","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"year":"1931","series-title":"Translated by K. 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