{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T04:21:24Z","timestamp":1746073284240,"version":"3.40.4"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>The antidiarrheal effects of chloroform, methanol, and aqueous extracts of<jats:italic>Bidens odorata<\/jats:italic>Cav. were investigated at doses of 200\u2009mg\/kg on castor-oil-induced diarrhea. The chloroform extract of<jats:italic>B. odorata<\/jats:italic>(CBO) reduced diarrhea by 72.72%. The effect of CBO was evaluated on mice with diarrhea induced by castor oil, MgSO<jats:sub>4<\/jats:sub>, arachidonic acid, or prostaglandin E<jats:sub>2<\/jats:sub>. CBO inhibited the contraction induced by carbachol chloride on ileum (100\u2009\u00b5g\/mL) and intestinal transit (200\u2009mg\/kg) in Wistar rats. The active fraction of CBO (F4) at doses of 100\u2009mg\/kg inhibited the diarrhea induced by castor oil (90.1%) or arachidonic acid (72.9%) but did not inhibit the diarrhea induced by PGE<jats:sub>2<\/jats:sub>. The active fraction of F4 (FR5) only was tested on diarrhea induced with castor oil and inhibited this diarrhea by 92.1%. The compositions of F4 and FR5 were determined by GC-MS, and oleic, palmitic, linoleic, and stearic acids were found. F4 and a mixture of the four fatty acids inhibited diarrhea at doses of 100\u2009mg\/kg (90.1% and 70.6%, resp.). The results of this study show that<jats:italic>B. odorata<\/jats:italic>has antidiarrheal effects, as is claimed by folk medicine, and could possibly be used for the production of a phytomedicine.<\/jats:p>","DOI":"10.1155\/2013\/170290","type":"journal-article","created":{"date-parts":[[2013,10,27]],"date-time":"2013-10-27T21:01:18Z","timestamp":1382907678000},"page":"1-7","source":"Crossref","is-referenced-by-count":8,"title":["Composition and Antidiarrheal Activity of<i>Bidens odorata<\/i>Cav."],"prefix":"10.1155","volume":"2013","author":[{"given":"Daniel","family":"Zavala-Mendoza","sequence":"first","affiliation":[{"name":"Experimental Biology P.h.D Program, D.C.B.S. Universidad Aut\u00f3noma Metropolitana-Iztapalapa, 09340 M\u00e9xico, DF, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J.","family":"Alarcon-Aguilar","sequence":"additional","affiliation":[{"name":"Departamento Ciencias de la Salud, D.C.B.S. Universidad Aut\u00f3noma Metropolitana-Iztapalapa, Avenida San Rafael Atlixco No. 186, Colonia Vicentina, Iztapalapa, 09340 M\u00e9xico, DF, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3152-4283","authenticated-orcid":true,"given":"Salud","family":"P\u00e9rez-Gutierrez","sequence":"additional","affiliation":[{"name":"Departamento de Sistemas Biol\u00f3gicos, Universidad Aut\u00f3noma Metropolitana-Xochimilco, Calzada del Hueso 1100, Colonia Villa Quietud, Coyoac\u00e1n, 09340 M\u00e9xico, DF, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Carmen","family":"Escobar-Villanueva","sequence":"additional","affiliation":[{"name":"Departamento Ciencias de la Salud, D.C.B.S. Universidad Aut\u00f3noma Metropolitana-Iztapalapa, Avenida San Rafael Atlixco No. 186, Colonia Vicentina, Iztapalapa, 09340 M\u00e9xico, DF, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Zavala-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Departamento de Sistemas Biol\u00f3gicos, Universidad Aut\u00f3noma Metropolitana-Xochimilco, Calzada del Hueso 1100, Colonia Villa Quietud, Coyoac\u00e1n, 09340 M\u00e9xico, DF, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.07.050054"},{"year":"1994","key":"3"},{"year":"1968","key":"4"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.08.005"},{"year":"1999","key":"6"},{"issue":"4","key":"7","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1055\/s-2006-959694","volume":"59","year":"1993","journal-title":"Planta Medica"},{"issue":"1","key":"8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.2042-7158.1988.tb05163.x","volume":"40","year":"1988","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"13","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0022-3565(25)03549-9","volume":"96","year":"1949","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"year":"2001","key":"15"},{"issue":"3","key":"9","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.2042-7158.1983.tb04295.x","volume":"35","year":"1983","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1540\/jsmr.46.107"},{"issue":"4","key":"11","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/BF01234480","volume":"54","year":"1983","journal-title":"Archives of Toxicology"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701130"},{"issue":"1","key":"17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.2042-7158.1978.tb13150.x","volume":"30","year":"1978","journal-title":"Journal of Pharmacy and Pharmacology"},{"issue":"1","key":"19","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0022-3565(25)38478-8","volume":"268","year":"1994","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(98)01249-8"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.82.168"},{"key":"22","first-page":"8","volume":"2","year":"2000","journal-title":"Hamdard Medicus XLIII"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M500564-JLR200"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00300.2007"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.00976.x"},{"issue":"6","key":"30","doi-asserted-by":"crossref","first-page":"G1388","DOI":"10.1152\/ajpgi.00141.2002","volume":"283","year":"2002","journal-title":"American Journal of Physiology\u2014Gastrointestinal and Liver Physiology"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00397.2009"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024699"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1100072"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/170290.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/170290.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/170290.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T18:28:35Z","timestamp":1746037715000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ecam\/2013\/170290\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":25,"alternative-id":["170290","170290"],"URL":"https:\/\/doi.org\/10.1155\/2013\/170290","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"type":"print","value":"1741-427X"},{"type":"electronic","value":"1741-4288"}],"subject":[],"published":{"date-parts":[[2013]]}}}