{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:40:49Z","timestamp":1779896449559,"version":"3.53.1"},"reference-count":29,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Here we aimed to determine the therapeutic effect of allicin on ankylosing spondylitis (AS) and explore the mechanism(s) of action. AS mouse model was constructed by transferring the HLA-B2704 gene into Kunming mice and verified by RT-PCR and CT imaging. Verified AS mice were randomly divided into model group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>6<\/mml:mn><\/mml:mrow><\/mml:math>) and allicin-treated groups (50, 100, and 200\u2009mg\/kg, resp.,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>6<\/mml:mn><\/mml:mrow><\/mml:math>, p.o., for 2 months). Wild type mice were used as control (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>6<\/mml:mn><\/mml:mrow><\/mml:math>). The levels of AS-related inflammatory factors were measured by ELISA. mRNA and protein expressions of HLA-B27 were checked by RT-PCR and western blotting. As the results, the mouse model of AS was successfully established, and high-dose allicin could markedly alleviate spine inflammatory injury possibly via reducing the secretion of the inflammatory factors (IL-6, IL-8, and TNF-<jats:italic>\u03b1<\/jats:italic>) sharply in AS mice. Moreover, allicin significantly inhibited HLA-B27 protein translation but failed to suppress HLA-B27 gene transcription in AS mice, indicating a posttranscriptional mechanism of this modulation. In conclusion, allicin has potential to be used for AS treatment as an anti-inflammatory nutraceutical.<\/jats:p>","DOI":"10.1155\/2013\/171573","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T21:20:38Z","timestamp":1384377638000},"page":"1-6","source":"Crossref","is-referenced-by-count":33,"title":["Allicin Attenuates Inflammation and Suppresses HLA-B27 Protein Expression in Ankylosing Spondylitis Mice"],"prefix":"10.1155","volume":"2013","author":[{"given":"Xin","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Shanghai Tenth People\u2019s Hospital Affiliated to TongJi University, Shanghai 20072, China"},{"name":"Department of Orthopaedics, The Second Affiliated Hospital of the Second Military Medical University, No. 415 Fengyang Road, Huangpu District, Shanghai 200003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haishan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Second Affiliated Hospital of the Second Military Medical University, No. 415 Fengyang Road, Huangpu District, Shanghai 200003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiliang","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Second Affiliated Hospital of the Second Military Medical University, No. 415 Fengyang Road, Huangpu District, Shanghai 200003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"issue":"12","key":"1","first-page":"2140","volume":"23","year":"1996","journal-title":"The Journal of 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