{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:17:11Z","timestamp":1740140231240,"version":"3.37.3"},"reference-count":88,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81202768","2010CB530500","1208085MH147","KJ2011ZD05"],"award-info":[{"award-number":["81202768","2010CB530500","1208085MH147","KJ2011ZD05"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["81202768","2010CB530500","1208085MH147","KJ2011ZD05"],"award-info":[{"award-number":["81202768","2010CB530500","1208085MH147","KJ2011ZD05"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003995","name":"Anhui Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["81202768","2010CB530500","1208085MH147","KJ2011ZD05"],"award-info":[{"award-number":["81202768","2010CB530500","1208085MH147","KJ2011ZD05"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Anhui Provincial Education Commission","award":["81202768","2010CB530500","1208085MH147","KJ2011ZD05"],"award-info":[{"award-number":["81202768","2010CB530500","1208085MH147","KJ2011ZD05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>In recent years, neuroimaging studies of acupuncture have explored extensive aspects of brain responses to acupuncture in finding its underlying mechanisms. Most of these studies have been performed on healthy adults. Only a few studies have been performed on patients with diseases. Brain responses to acupuncture in patients with the same disease at different pathological stages have not been explored, although it may be more important and helpful in uncovering its underlying mechanisms. In the present study, we used fMRI to compare brain responses to acupuncture in patients with Bell\u2019s palsy at different pathological stages with normal controls and found that the brain response to acupuncture varied at different pathological stages of Bell\u2019s palsy. The brain response to acupuncture decreased in the early stages, increased in the later stages, and nearly returned to normal in the recovered group. All of the changes in the brain response to acupuncture could be explained as resulting from the changes in the brain functional status. Therefore, we proposed that the brain response to acupuncture is dependent on the brain functional status, while further investigation is needed to provide more evidence in support of this proposition.<\/jats:p>","DOI":"10.1155\/2013\/175278","type":"journal-article","created":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T21:03:30Z","timestamp":1369170210000},"page":"1-14","source":"Crossref","is-referenced-by-count":9,"title":["Brain Responses to Acupuncture Are Probably Dependent on the Brain Functional Status"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3023-9755","authenticated-orcid":true,"given":"Chuanfu","family":"Li","sequence":"first","affiliation":[{"name":"Laboratory of Digital Medical Imaging, The First Affiliated Hospital of Anhui University of TCM, Hefei, Anhui 230031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4849-7402","authenticated-orcid":true,"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Laboratory of Digital Medical Imaging, The First Affiliated Hospital of Anhui University of TCM, Hefei, Anhui 230031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinbo","family":"Sun","sequence":"additional","affiliation":[{"name":"Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi 710071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunsheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Laboratory of Digital Medical Imaging, The First Affiliated Hospital of Anhui University of TCM, Hefei, Anhui 230031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanqiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi 710071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5333-8158","authenticated-orcid":true,"given":"Qi","family":"Lu","sequence":"additional","affiliation":[{"name":"Laboratory of Digital Medical Imaging, The First Affiliated Hospital of Anhui University of TCM, Hefei, Anhui 230031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3549-5966","authenticated-orcid":true,"given":"Aihong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Laboratory of Digital Medical Imaging, The First Affiliated Hospital of Anhui University of TCM, Hefei, Anhui 230031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3484-2631","authenticated-orcid":true,"given":"Yifang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Laboratory of Digital Medical Imaging, The First Affiliated Hospital of Anhui University of TCM, Hefei, Anhui 230031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2490-5985","authenticated-orcid":true,"given":"Luoyi","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Digital Medical Imaging, The First Affiliated Hospital of Anhui University of TCM, Hefei, Anhui 230031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8422-4014","authenticated-orcid":true,"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Digital Medical Imaging, The First Affiliated Hospital of Anhui University of TCM, Hefei, Anhui 230031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8531-5869","authenticated-orcid":true,"given":"Junping","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Digital Medical Imaging, The First Affiliated Hospital of Anhui University of TCM, Hefei, Anhui 230031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3181-3026","authenticated-orcid":true,"given":"Jianjun","family":"Huang","sequence":"additional","affiliation":[{"name":"Laboratory of Digital Medical Imaging, The First Affiliated Hospital of Anhui University of TCM, Hefei, Anhui 230031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5615-9879","authenticated-orcid":true,"given":"Dongxiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Digital Medical Imaging, The First Affiliated Hospital of Anhui University of TCM, Hefei, Anhui 230031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8023-0823","authenticated-orcid":true,"given":"Linying","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Digital Medical Imaging, The First Affiliated Hospital of Anhui University of TCM, Hefei, Anhui 230031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Qin","sequence":"additional","affiliation":[{"name":"Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi 710071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Tian","sequence":"additional","affiliation":[{"name":"Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi 710071, China"},{"name":"Key Laboratory of Complex Systems and Intelligence Science, Institute of Automation, Chinese Academy of Sciences, P.O. Box 2728, Beijing 100190, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.08.006"},{"issue":"2","key":"2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.biomed.2012.04.004","volume":"2","year":"2012","journal-title":"BioMedicine"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S2005-2901(09)60012-1"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jams.2012.05.001"},{"issue":"1","key":"5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ejim.2011.07.017","volume":"23","year":"2012","journal-title":"European Journal of Internal Medicine"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.11.004"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.10.012"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)02983-4"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2004.01.074"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.02.017"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.04.037"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.04.021"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.10.019"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-007-0010-3"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2007.01.010"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.01.001"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2008.01.058"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.01.011"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.04.020"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20769"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.03.060"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2008.11.048"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.07.015"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.12.025"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnsc.2008.09.009"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.05.079"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(09)70963-2"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.05.087"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.08.009"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2008.10.071"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.04.056"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.06.061"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.05.077"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.09.040"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.06.091"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2009.0395"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2009.11.009"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.11.031"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2010.03.022"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.12.019"},{"issue":"8","key":"41","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.mri.2011.06.002","volume":"29","year":"2011","journal-title":"Magnetic Resonance Imaging"},{"issue":"3","key":"42","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.dza.2011.07.008","volume":"54","year":"2011","journal-title":"Deutsche Zeitschrift f\u00fcr Akupunktur"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20583"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.12.003"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.03.080"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/S2005-2901(10)60009-X"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2010.11.004"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.03.063"},{"issue":"5","key":"49","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.mri.2012.01.003","volume":"30","year":"2012","journal-title":"Magnetic Resonance Imaging"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-011-0861-5"},{"issue":"1","key":"51","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s11655-011-0861-5","volume":"18","year":"2012","journal-title":"Chinese Journal of Integrative Medicine"},{"issue":"2","key":"52","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0254-6272(10)60033-7","volume":"30","year":"2010","journal-title":"Journal of Traditional Chinese Medicine"},{"issue":"2","key":"53","first-page":"152","volume":"7","year":"2012","journal-title":"Neural Regeneration Research"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1136\/aim.2009.000638"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-2011-0592"},{"first-page":"133","volume-title":"Facial nerve palsy","year":"2011","key":"56"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.12.031"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/467061"},{"issue":"7","key":"61","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/j.neuropsychologia.2012.03.015","volume":"50","year":"2012","journal-title":"Neuropsychologia"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2008.11.001"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1016\/j.neunet.2009.06.047"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.01.056"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1016\/j.neunet.2011.03.021"},{"issue":"1","key":"66","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.neuroimage.2011.07.017","volume":"59","year":"2012","journal-title":"NeuroImage"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.12.031"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2009.09.009"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.10.046"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(03)43047-1"},{"issue":"7","key":"71","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.tics.2012.06.002","volume":"16","year":"2012","journal-title":"Trends in Cognitive Sciences"},{"issue":"3","key":"72","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jpain.2012.11.011","volume":"14","year":"2013","journal-title":"The Journal of Pain"},{"issue":"4","key":"73","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.neuroimage.2012.04.011","volume":"61","year":"2012","journal-title":"NeuroImage"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2010.05.005"},{"issue":"2","key":"75","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1016\/j.neuroimage.2011.08.065","volume":"59","year":"2012","journal-title":"NeuroImage"},{"issue":"3","key":"76","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1016\/j.neuroimage.2011.08.039","volume":"59","year":"2012","journal-title":"NeuroImage"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2009.10.004"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2009.06.009"},{"issue":"4","key":"79","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.neuroimage.2012.03.044","volume":"61","year":"2012","journal-title":"NeuroImage"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00106.2011"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00834.2010"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01117.2009"},{"issue":"5","key":"83","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1152\/jn.00339.2011","volume":"106","year":"2011","journal-title":"Journal of Neurophysiology"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.07.026"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3398-09.2009"},{"issue":"4","key":"85","first-page":"209","volume":"2","year":"2010","journal-title":"European Journal of Integrative Medicine"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2009.05.009"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.11.006"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2010.03.008"},{"issue":"6","key":"89","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jams.2012.07.017","volume":"5","year":"2012","journal-title":"Journal of Acupuncture and Meridian Studies"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/175278.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/175278.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/175278.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T16:08:56Z","timestamp":1588954136000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ecam\/2013\/175278\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":88,"alternative-id":["175278","175278"],"URL":"https:\/\/doi.org\/10.1155\/2013\/175278","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"type":"print","value":"1741-427X"},{"type":"electronic","value":"1741-4288"}],"subject":[],"published":{"date-parts":[[2013]]}}}