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Here, we optimized the dog model of experimental OA induced by cranial cruciate ligament sectioning. The usefulness of noninvasive complementary outcome measures, such as gait analysis for the limb function and magnetic resonance imaging for structural changes, was demonstrated in this model. Relationships were established between the functional impairment and the severity of structural changes including the measurement of cartilage thinning. In the dog model of naturally occurring OA, excellent test-retest reliability was denoted for the measurement of the limb function. A criterion to identify clinically meaningful responders to therapy was determined for privately owned dogs undergoing clinical trials. In addition, the recording of accelerometer-based duration of locomotor activity showed strong and complementary agreement with the biomechanical limb function. The translation potential of these models to the human OA condition is underlined. A preclinical testing protocol which combines the dog model of experimental OA induced by cranial cruciate ligament transection and the Dog model of naturally occurring OA offers the opportunity to further investigate the structural and functional benefits of disease-modifying strategies. Ultimately, a better prediction of outcomes for human clinical trials would be brought.\n                  <\/jats:p>","DOI":"10.1155\/2013\/180453","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T23:07:50Z","timestamp":1383260870000},"page":"1-12","source":"Crossref","is-referenced-by-count":30,"title":["A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis"],"prefix":"10.1155","volume":"2013","author":[{"given":"Maxim","family":"Moreau","sequence":"first","affiliation":[{"name":"Osteoarthritis Research Unit, Universit\u00e9 de Montr\u00e9al Hospital Centre, Notre-Dame Hospital, 1560 Sherbrooke St. East, Montreal, QC, Canada H2L 4M1"},{"name":"GREPAQ, Department of Veterinary Biomedical Sciences, Faculty of Veterinary Medicine (FVM), Universit\u00e9 de Montr\u00e9al, P.O. Box 5000, Saint-Hyacinthe, QC, Canada J2S 7C6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Osteoarthritis Research Unit, Universit\u00e9 de Montr\u00e9al Hospital Centre, Notre-Dame Hospital, 1560 Sherbrooke St. East, Montreal, QC, Canada H2L 4M1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Lussier","sequence":"additional","affiliation":[{"name":"Osteoarthritis Research Unit, Universit\u00e9 de Montr\u00e9al Hospital Centre, Notre-Dame Hospital, 1560 Sherbrooke St. East, Montreal, QC, Canada H2L 4M1"},{"name":"Department of Clinical Sciences, FVM, Universit\u00e9 de Montr\u00e9al, P.O. 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