{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:50:14Z","timestamp":1780635014298,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Both studies on animals and humans suggest the presence of dopamine (DA) receptors in the anterior segment of the eye. Their role in the dynamics of intraocular pressure (IOP) is not yet clear. DA<jats:sub>2<\/jats:sub>and DA<jats:sub>3<\/jats:sub>receptors are mainly located on postganglionic sympathetic nerve endings. Their stimulation reduces the release of norepinephrine and suppresses the production of aqueous humor. DA<jats:sub>1<\/jats:sub>receptors seem to be more expressed by the ciliary body and the outflow pathway of aqueous humor. The administration of DA<jats:sub>1<\/jats:sub>-selective agonists stimulates the production of aqueous humor, increasing IOP, whereas DA<jats:sub>2<\/jats:sub>- and DA<jats:sub>3<\/jats:sub>-selective agonists could reduce IOP and, therefore, the risk to develop a glaucoma (GL). GL is a broad spectrum of eye diseases which have in common the damage to the optic nerve and the progressive loss of the visual field. Further studies are desirable to clarify the role of the dopaminergic system and the usefulness of DA<jats:sub>2<\/jats:sub>and DA<jats:sub>3<\/jats:sub>agonists in reducing IOP.<\/jats:p>","DOI":"10.1155\/2013\/193048","type":"journal-article","created":{"date-parts":[[2013,6,26]],"date-time":"2013-06-26T17:01:32Z","timestamp":1372266092000},"page":"1-5","source":"Crossref","is-referenced-by-count":22,"title":["Role of Dopaminergic Receptors in Glaucomatous Disease Modulation"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4280-2629","authenticated-orcid":true,"given":"Nicola","family":"Pescosolido","sequence":"first","affiliation":[{"name":"Department of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences, Sapienza University of Rome, Piazzale Aldo Moro 5, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Parisi","sequence":"additional","affiliation":[{"name":"Department of Sense Organs, Centre of Ocular Electrophysiology, Sapienza University of Rome, Piazzale Aldo Moro 5, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Sense Organs, Centre of Ocular Electrophysiology, Sapienza University of Rome, Piazzale Aldo Moro 5, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Buomprisco","sequence":"additional","affiliation":[{"name":"Department of Sense Organs, Centre of Ocular Electrophysiology, Sapienza University of Rome, Piazzale Aldo Moro 5, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5512-0849","authenticated-orcid":true,"given":"Marcella","family":"Nebbioso","sequence":"additional","affiliation":[{"name":"Department of Sense Organs, Centre of Ocular Electrophysiology, Sapienza University of Rome, Piazzale Aldo Moro 5, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.081224"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61423-7"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/202905"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3109\/01913123.2011.634090"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.4081\/ejh.2012.e42"},{"issue":"5","key":"6","first-page":"S45","volume":"10","year":"2001","journal-title":"Journal of Glaucoma"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010611419602"},{"issue":"11","key":"8","first-page":"887","volume":"82","year":"2004","journal-title":"Bulletin of the World Health Organization"},{"issue":"4","key":"9","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0014-4835(79)90059-9","volume":"29","year":"1979","journal-title":"Experimental Eye Research"},{"issue":"12","key":"10","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/0024-3205(79)90037-7","volume":"24","year":"1979","journal-title":"Life Sciences"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(90)90079-A"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/1350-9462(95)00005-4"},{"issue":"2-3","key":"13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF01273174","volume":"104","year":"1997","journal-title":"Journal of Neural Transmission"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2011.11.031"},{"issue":"5","key":"15","first-page":"371","volume":"15","year":"1976","journal-title":"Investigative Ophthalmology"},{"issue":"3","key":"16","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0014-4835(81)80047-4","volume":"33","year":"1981","journal-title":"Experimental Eye Research"},{"issue":"6","key":"17","doi-asserted-by":"crossref","first-page":"851","DOI":"10.3109\/02713688409000798","volume":"3","year":"1984","journal-title":"Current Eye Research"},{"issue":"6","key":"18","first-page":"644","volume":"346","year":"1992","journal-title":"Naunyn-Schmiedeberg's Archives of Pharmacology"},{"issue":"11","key":"19","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1177\/34.11.2877023","volume":"34","year":"1986","journal-title":"The Journal of Histochemistry and Cytochemistry"},{"issue":"5","key":"20","first-page":"281","volume":"2","year":"1983","journal-title":"Current Eye Research"},{"issue":"11","key":"21","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.3109\/02713688409007415","volume":"3","year":"1984","journal-title":"Current Eye Research"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1211\/002235703765951393"},{"issue":"3","key":"23","first-page":"710","volume":"293","year":"2000","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"8336","key":"24","first-page":"1250","volume":"1","year":"1983","journal-title":"The Lancet"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90162-4"},{"issue":"43","key":"26","first-page":"1656","volume":"108","year":"1983","journal-title":"Deutsche Medizinische Wochenschrift"},{"issue":"1\u20133","key":"27","first-page":"53","volume":"20","year":"1997","journal-title":"International Ophthalmology"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1007\/BF02336684"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1007\/BF00917989"},{"issue":"5","key":"30","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/0014-4835(88)90036-X","volume":"47","year":"1988","journal-title":"Experimental Eye Research"},{"issue":"3","key":"31","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1089\/jop.1998.14.203","volume":"14","year":"1998","journal-title":"Journal of Ocular Pharmacology and Therapeutics"},{"issue":"9","key":"32","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/S0161-6420(95)30872-X","volume":"102","year":"1995","journal-title":"Ophthalmology"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.28.3.189.26252"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1159\/000082779"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3182311db4"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/193048.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/193048.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/193048.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T11:19:00Z","timestamp":1498043940000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2013\/193048\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":35,"alternative-id":["193048","193048"],"URL":"https:\/\/doi.org\/10.1155\/2013\/193048","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}