{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T20:19:18Z","timestamp":1648844358432},"reference-count":11,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Endocrinology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. There have been six previous cases that reported pseudopheochromocytoma in patients taking clozapine. Our case showed the direct link of clozapine to serum levels of certain markers.<jats:italic>Case<\/jats:italic>. This is a case of a 49-year-old obese Caucasian female who was referred to endocrinology for investigation of Cushing\u2019s syndrome, based on raised blood pressure and Cushingoid facies. The patient had underlying schizophrenia and was stable on clozapine. Her blood pressure was 150\/99\u2009mmHg on bendroflumethiazide and candesartan. We measured her 24-hour urinary-free cortisol, which was normal but 24-hour urinary-free noradrenaline was elevated at 835\u2009nmol (76\u2013561) with normal adrenaline 36\u2009nmol (7\u201382) and dopamine 2679\u2009nmol (366\u20132879), as the patient had history of palpitations and sweating. Two sets of 24-hour urinary-free cortisol measurements were normal and serum cortisol suppressed to &lt;50\u2009nmol\/l after a 1\u2009mg overnight dexamethasone. Two further 24-hour urinary-free catecholamines showed a raised level of noradrenaline. MRI demonstrated normal adrenals and MIBG scan did not show any abnormal uptake at adrenal glands.<jats:italic>Conclusion<\/jats:italic>. Pseudopheochromocytoma has been reported in patients taking clozapine. A number of different mechanisms for raised plasma noradrenaline levels with clozapine have been postulated. The above case highlights an unusual but known side effect of clozapine.<\/jats:p>","DOI":"10.1155\/2013\/194927","type":"journal-article","created":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T22:00:26Z","timestamp":1358200826000},"page":"1-3","source":"Crossref","is-referenced-by-count":2,"title":["Clozapine Use Presenting with Pseudopheochromocytoma in a Schizophrenic Patient: A Case Report"],"prefix":"10.1155","volume":"2013","author":[{"given":"Jaskanwal","family":"Sara","sequence":"first","affiliation":[{"name":"University Hospitals Coventry and Warwickshire NHS Trust, Coventry CV2 2DX, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Waikato General Hospital, Hamilton 3240, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanveer","family":"Chohan","sequence":"additional","affiliation":[{"name":"University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karan","family":"Jolly","sequence":"additional","affiliation":[{"name":"Walsall Healthcare NHS Trust, Walsall WS2 9PS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Diabetes and Endocrinology, Birmingham Heartlands Hospital, Heart of England Foundation Trust, Birmingham B9 5SS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirav Y.","family":"Gandhi","sequence":"additional","affiliation":[{"name":"College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayadave","family":"Shakher","sequence":"additional","affiliation":[{"name":"Diabetes and Endocrinology, Birmingham Heartlands Hospital, Heart of England Foundation Trust, Birmingham B9 5SS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"issue":"6","key":"1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3109\/00048679709065519","volume":"31","year":"1997","journal-title":"Australian and New Zealand Journal of Psychiatry"},{"issue":"7296","key":"2","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1136\/bmj.322.7296.1213","volume":"322","year":"2001","journal-title":"British Medical Journal"},{"issue":"4","key":"3","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1017\/S0790966700007941","volume":"20","year":"2003","journal-title":"Irish Journal of Psychological Medicine"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(93)90017-B"},{"issue":"9","key":"5","first-page":"122","volume":"55","year":"1994","journal-title":"Journal of Clinical Psychiatry"},{"issue":"2","key":"6","first-page":"139","volume":"21","year":"1998","journal-title":"Clinical Neuropharmacology"},{"issue":"1","key":"7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/npp.1994.1","volume":"10","year":"1994","journal-title":"Neuropsychopharmacology"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(98)00047-5"},{"issue":"16","key":"9","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1001\/archinte.160.16.2521","volume":"160","year":"2000","journal-title":"Archives of Internal Medicine"},{"issue":"2","key":"10","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/hup.470040212","volume":"4","year":"1989","journal-title":"Human Psychopharmacology"},{"issue":"3","key":"11","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1176\/ajp.151.3.462","volume":"151","year":"1994","journal-title":"American Journal of Psychiatry"}],"container-title":["Case Reports in Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crie\/2013\/194927.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crie\/2013\/194927.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crie\/2013\/194927.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T05:38:23Z","timestamp":1498023503000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crie\/2013\/194927\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":11,"alternative-id":["194927","194927"],"URL":"https:\/\/doi.org\/10.1155\/2013\/194927","relation":{},"ISSN":["2090-6501","2090-651X"],"issn-type":[{"value":"2090-6501","type":"print"},{"value":"2090-651X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}