{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:42:02Z","timestamp":1783485722505,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Gitelman\u2019s syndrome (GS) is autosomal recessive renal tubular disorder characterized by hypokalemia, hypomagnesemia, hypocalciuria, metabolic alkalosis, and hyperreninemic hyperaldosteronism. It is usually associated with normal serum calcium. We report a patient presented with hypocalcemic tetany, and evaluation showed Gitelman\u2019s syndrome with hypocalcemia.<jats:italic>Case Report<\/jats:italic>. A 28-year-old woman presented with cramps of the arms, legs, fatigue, and carpal spasms of one week duration. She has history of similar episodes on and off for the past two years. Her blood pressure was 98\/66\u2009mmHg. Chvostek\u2019s sign and Trousseau\u2019s sign were positive. Evaluation showed hypokalemia, hypocalcemia, hypomagnesemia, metabolic alkalosis, and hypocalciuria. Self-medication, diuretic use, laxative abuse, persistent vomiting, and diarrhoea were ruled out. Urinary prostaglandins and genetic testing could not be done because of nonavailability. To differentiate Gitelman syndrome from Bartter\u2019s syndrome (BS), thiazide loading test was done. It showed blunted fractional chloride excretion. GS was confirmed and patient was treated with spironolactone along with magnesium, calcium, and potassium supplementation. Symptomatically, she improved and did not develop episodes of tetany again.<jats:italic>Conclusion<\/jats:italic>. In tetany patient along with serum calcium measurement, serum magnesium, serum potassium, and arterial blood gases should be measured. Even though hypocalcemia in Gitelman syndrome is rare, it still can occur.<\/jats:p>","DOI":"10.1155\/2013\/197374","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T20:42:05Z","timestamp":1379623325000},"page":"1-3","source":"Crossref","is-referenced-by-count":4,"title":["Calcium Unresponsive Hypocalcemic Tetany: Gitelman Syndrome with Hypocalcemia"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9277-0517","authenticated-orcid":true,"given":"Madhav","family":"Desai","sequence":"first","affiliation":[{"name":"Department of Nephrology, Narayana Medical College, Chintareddypalem, Nellore, Andhra Pradesh 524003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen Kumar","family":"Kolla","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Narayana Medical College, Chintareddypalem, Nellore, Andhra Pradesh 524003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9439-7904","authenticated-orcid":true,"given":"P. L. Venkata Pakki","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Narayana Medical College, Chintareddypalem, Nellore, Andhra Pradesh 524003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","first-page":"221","volume":"79","year":"1966","journal-title":"Transactions of the Association of American Physicians"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02950906"},{"issue":"5","key":"7","first-page":"464","volume":"28","year":"2005","journal-title":"Journal of Endocrinological Investigation"},{"issue":"4","key":"8","first-page":"583","volume":"36","year":"2005","journal-title":"Journal of Sichuan University (Medical Science Edition)"},{"issue":"4","key":"9","doi-asserted-by":"crossref","first-page":"567","DOI":"10.3346\/jkms.2002.17.4.567","volume":"17","year":"2002","journal-title":"Journal of Korean medical science"},{"issue":"1","key":"10","first-page":"67","volume":"40","year":"2008","journal-title":"Kuwait Medical Journal"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(98)00196-X"},{"issue":"1","key":"4","first-page":"29","volume":"16","year":"1994","journal-title":"Magnesium Bull"},{"issue":"4","key":"5","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1210\/jcem-42-4-707","volume":"42","year":"1976","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"3","key":"6","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1365-2265.1976.tb01947.x","volume":"5","year":"1976","journal-title":"Clinical Endocrinology"}],"container-title":["Case Reports in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2013\/197374.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2013\/197374.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2013\/197374.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T18:14:26Z","timestamp":1498068866000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crim\/2013\/197374\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":10,"alternative-id":["197374","197374"],"URL":"https:\/\/doi.org\/10.1155\/2013\/197374","relation":{},"ISSN":["1687-9627","1687-9635"],"issn-type":[{"value":"1687-9627","type":"print"},{"value":"1687-9635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}