{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:28:23Z","timestamp":1791851303081,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC100-2314-B182-002-MY3"],"award-info":[{"award-number":["NSC100-2314-B182-002-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Alertness to dengue and making a timely diagnosis is extremely important in the treatment of dengue and containment of dengue epidemics. We evaluated the complementary role of clinical-practice-based laboratory data in facilitating suspicion\/diagnosis of dengue. One hundred overall dengue (57 dengue fever [DF] and 43 dengue hemorrhagic fever [DHF]) cases and another 100 nondengue cases (78 viral infections other than dengue, 6 bacterial sepsis, and 16 miscellaneous diseases) were analyzed. We separately compared individual laboratory variables (platelet count [PC] , prothrombin time [PT], activated partial thromboplastin time [APTT], alanine aminotransferase [ALT], and aspartate aminotransferase [AST]) and varied combined variables of DF and\/or DHF cases with the corresponding ones of nondengue cases. The sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) in the diagnosis of DF and\/or DHF were measured based on these laboratory variables. While trade-off between sensitivity and specificity, and\/or suboptimal PPV\/NPV was found at measurements using these variables, prolonged APTT + normal PT + PC &lt; 100 \u00d7 10<jats:sup>9<\/jats:sup>cells\/L had a favorable sensitivity, specificity, PPV, and NPV in diagnosis of DF and\/or DHF. In conclusion, these data suggested that prolonged APTT + normal PT + PC &lt; 100 \u00d7 10<jats:sup>9<\/jats:sup>cells\/L is useful in evaluating the likelihood of DF and\/or DHF.<\/jats:p>","DOI":"10.1155\/2013\/198797","type":"journal-article","created":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T21:02:31Z","timestamp":1387486951000},"page":"1-11","source":"Crossref","is-referenced-by-count":13,"title":["The Usefulness of Clinical-Practice-Based Laboratory Data in Facilitating the Diagnosis of Dengue Illness"],"prefix":"10.1155","volume":"2013","author":[{"given":"Jien-Wei","family":"Liu","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan"},{"name":"Infection Control Team, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan"},{"name":"Chang Gung University College of Medicine, Tao-Yuan 333, 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