{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T17:19:25Z","timestamp":1723051165295},"reference-count":36,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Adenocarcinoma of the ampulla of Vater (AAV) is a rare malignancy that has a better prognosis than other periampullary cancers. However, the standard treatment for patients with relapsed or metastatic AAV has not been established. We investigated the clinical feasibility of standardized allergen-removed<jats:italic>Rhus verniciflua<\/jats:italic>stokes (aRVS) extract for advanced or metastatic AAV.<jats:italic>Patients and Methods<\/jats:italic>. From July 2006 to April 2011, we retrospectively reviewed all patients with advanced AAV treated with aRVS extract alone. After applying inclusion\/exclusion criteria, 12 patients were eligible for the final analysis. We assessed the progression-free survival (PFS) and overall survival (OS) of these patients during the follow-up period.<jats:italic>Results<\/jats:italic>. The median aRVS administration period was 147.0 days (range: 72\u2013601 days). The best tumor responses according to Response Evaluation Criteria in Solid Tumors were as follows: two with complete response, two with stable disease, and eight with progressive disease. The median OS was 15.1 months (range: 4.9\u201325.1 months), and the median PFS was 3.0 months (range: 1.6\u201311.4 months). Adverse reactions to the aRVS treatment were mostly mild and self-limiting.<jats:italic>Conclusions<\/jats:italic>. Prolonged survival was observed in patients with advanced AAV under the treatment of standardized aRVS extract without significant adverse effects.<\/jats:p>","DOI":"10.1155\/2013\/203168","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T02:59:59Z","timestamp":1366685999000},"page":"1-8","source":"Crossref","is-referenced-by-count":7,"title":["Impact of Standardized Allergen-Removed<i>Rhus verniciflua<\/i>Stokes Extract on Advanced Adenocarcinoma of the Ampulla of Vater: A Case Series"],"prefix":"10.1155","volume":"2013","author":[{"given":"Woncheol","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Medical Consilence, Graduate School, Jukjeon Campus, Dankook University, 152 Jukjeon-ro, Suji-gu, Yongin-si 448-701, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soomin","family":"An","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Integrative Cancer Center, 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