{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:33:46Z","timestamp":1791293626572,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology Research and Practice"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>In recent years, technology has allowed the development of new diagnostic techniques which allow real-time,<jats:italic>in vivo<\/jats:italic>, noninvasive evaluation of morphological changes in tissue. This study compares and correlates the images and findings obtained by high-definition optical coherence tomography (HD-OCT) and reflectance confocal microscopy (RCM) with histology in normal healthy oral mucosa. The healthy lip mucosa of ten adult volunteers was imaged with HD-OCT and RCM. Each volunteer was systematically evaluated by RCM starting in the uppermost part of the epithelium down to the lamina propia. Afterwards, volunteers were examined with a commercially available full-field HD-OCT system using both the \u201cslice\u201d and the \u201cen-face\u201d mode. A \u201cpunch\u201d biopsy of the lower lip mucosa was obtained and prepared for conventional histology. The architectural overview offered by \u201cslice\u201d mode HD-OCT correlates with histologic findings at low magnification. In the superficial uppermost layers of the epithelium, RCM imaging provided greater cellular detail than histology. As we deepened into the suprabasal layers, the findings are in accordance with physiological cellular differentiation and correlate with the images obtained from conventional histology. The combined use of these two novel non-invasive imaging techniques provides morphological imaging with sufficient resolution and penetration depth, resulting in quasihistological images.<\/jats:p>","DOI":"10.1155\/2013\/205256","type":"journal-article","created":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T17:04:25Z","timestamp":1378227865000},"page":"1-8","source":"Crossref","is-referenced-by-count":19,"title":["<i>In Vivo<\/i>Noninvasive Imaging of Healthy Lower Lip Mucosa: A Correlation Study between High-Definition Optical Coherence Tomography, Reflectance Confocal Microscopy, and Histology"],"prefix":"10.1155","volume":"2013","author":[{"given":"Alejandra","family":"Garc\u00eda-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Melanoma Unit, Dermatology Department, Hospital Cl\u00ednic, C\/Villaroel 170, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6832-5915","authenticated-orcid":true,"given":"Rodrigo","family":"Rold\u00e1n-Mar\u00edn","sequence":"additional","affiliation":[{"name":"Melanoma Unit, Dermatology Department, Hospital Cl\u00ednic, C\/Villaroel 170, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Iglesias-Garcia","sequence":"additional","affiliation":[{"name":"Melanoma Unit, Dermatology Department, Hospital Cl\u00ednic, C\/Villaroel 170, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Malvehy","sequence":"additional","affiliation":[{"name":"Melanoma Unit, Dermatology Department, Hospital Cl\u00ednic, C\/Villaroel 170, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"5035","key":"1","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1126\/science.1957169","volume":"254","year":"1991","journal-title":"Science"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.11.040"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2006.08.009"},{"key":"4","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.1529-8019.2012.01495.x","volume":"25","year":"2012","journal-title":"Dermatology and Therapy"},{"key":"5","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/j.1600-0625.2012.01569.x","volume":"21","year":"2012","journal-title":"Experimental Dermatology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04551.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022877220226"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2005.00251.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1186\/1758-3284-4-29"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.10.1074"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21022"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1243624"},{"issue":"5","key":"13","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q","volume":"6","year":"1953","journal-title":"Cancer"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1586\/ERA.09.191"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20098"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1117\/1.2779025"},{"key":"17","volume":"14","year":"2009","journal-title":"Journal of Biomedical Optics"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199910000-00029"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.3109\/01913123.2013.776656"}],"container-title":["Dermatology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/drp\/2013\/205256.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/drp\/2013\/205256.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/drp\/2013\/205256.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T17:15:36Z","timestamp":1498065336000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/drp\/2013\/205256\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":19,"alternative-id":["205256","205256"],"URL":"https:\/\/doi.org\/10.1155\/2013\/205256","relation":{},"ISSN":["1687-6105","1687-6113"],"issn-type":[{"value":"1687-6105","type":"print"},{"value":"1687-6113","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}