{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T16:34:58Z","timestamp":1746808498348,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30972822","81273274","81001329","30972714","RC201170","XK201115"],"award-info":[{"award-number":["30972822","81273274","81001329","30972714","RC201170","XK201115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30972822","81273274","81001329","30972714","RC201170","XK201115"],"award-info":[{"award-number":["30972822","81273274","81001329","30972714","RC201170","XK201115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30972822","81273274","81001329","30972714","RC201170","XK201115"],"award-info":[{"award-number":["30972822","81273274","81001329","30972714","RC201170","XK201115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30972822","81273274","81001329","30972714","RC201170","XK201115"],"award-info":[{"award-number":["30972822","81273274","81001329","30972714","RC201170","XK201115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangsu Province\u2019s Key Provincial Talents Program","award":["30972822","81273274","81001329","30972714","RC201170","XK201115"],"award-info":[{"award-number":["30972822","81273274","81001329","30972714","RC201170","XK201115"]}]},{"name":"Key Allergy Laboratory Fund of Jiangsu Province, China","award":["30972822","81273274","81001329","30972714","RC201170","XK201115"],"award-info":[{"award-number":["30972822","81273274","81001329","30972714","RC201170","XK201115"]}]},{"name":"Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)","award":["30972822","81273274","81001329","30972714","RC201170","XK201115"],"award-info":[{"award-number":["30972822","81273274","81001329","30972714","RC201170","XK201115"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Local inflammation is a prominent characteristic of snakebite wound, and snake-venom phospholipase A<jats:sub>2<\/jats:sub>s (PLA<jats:sub>2<\/jats:sub>s) are some of the main component that contribute to accumulation of inflammatory cells. However, the action of an R49 PLA<jats:sub>2<\/jats:sub>s, promutoxin from<jats:italic>Protobothrops mucrosquamatus<\/jats:italic>venom, on mast-cell accumulation has not been previously examined. Using a mouse peritoneal model, we found that promutoxin can induce approximately-6-fold increase in mast-cell accumulation, and the response lasts at least for 16\u2009h. The promutoxin-induced mast cell accumulation was inhibited by cyproheptadine, terfenadine, and Ginkgolide B, indicating that histamine and platelet-activating factor (PAF) is likely to contribute to the mast-cells accumulation. Preinjection of antibodies against adhesion molecules ICAM-1, CD18, CD11a, and L-selectin showed that ICAM-1, and CD18, CD11a are key adhesion molecules of promutoxin-induced mast-cell accumulation. In conclusion, promutoxin can induce accumulation of mast cells, which may contribute to snake-venom wound.<\/jats:p>","DOI":"10.1155\/2013\/206061","type":"journal-article","created":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T21:03:27Z","timestamp":1356037407000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Induction of Mast-Cell Accumulation by Promutoxin, an Arg-49 Phospholipase<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msub><mml:mtext>A<\/mml:mtext><mml:mtext>2<\/mml:mtext><\/mml:msub><\/mml:mrow><\/mml:math>"],"prefix":"10.1155","volume":"2013","author":[{"given":"Ji-Fu","family":"Wei","sequence":"first","affiliation":[{"name":"Clinical Experiment Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China"},{"name":"Allergy and Inflammation Research Institute, The Shantou University Medical College, Shantou, Guangdong 515041, China"},{"name":"Research Division of Clinical Pharmacology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Long","family":"Wei","sequence":"additional","affiliation":[{"name":"Allergy and Inflammation Research Institute, The Shantou University Medical College, Shantou, Guangdong 515041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Zhen","family":"Mo","sequence":"additional","affiliation":[{"name":"Allergy and Inflammation Research Institute, The Shantou University Medical College, Shantou, Guangdong 515041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiwei","family":"Yang","sequence":"additional","affiliation":[{"name":"Clinical Experiment Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoheng","family":"He","sequence":"additional","affiliation":[{"name":"Clinical Experiment Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China"},{"name":"Allergy and Inflammation Research Institute, The Shantou University Medical College, Shantou, Guangdong 515041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"3","key":"1","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1042\/bj3190961","volume":"319","year":"1996","journal-title":"Biochemical Journal"},{"issue":"3","key":"2","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1111\/j.1432-1033.1991.tb16485.x","volume":"202","year":"1991","journal-title":"European Journal of Biochemistry"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.107.117747"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20030818"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2005.11.022"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2006.06.021"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2006.01.031"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2006.05.003"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(02)00141-1"},{"issue":"1","key":"10","first-page":"25","volume":"11","year":"2002","journal-title":"Journal of Natural Toxins"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2005.02.018"},{"issue":"3","key":"12","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1042\/bj3110895","volume":"311","year":"1995","journal-title":"Biochemical Journal"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2000.1790"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1999.1492"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)01288-1"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(93)90254-G"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(00)00248-3"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2003.11.006"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2005.06.017"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)01546-X"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1126\/science.1128877"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071262"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-10-21"},{"issue":"4","key":"24","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.toxicon.2009.12.016","volume":"55","year":"2010","journal-title":"Toxicon"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2010.05.018"},{"issue":"2","key":"26","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/oxfordjournals.jbchem.a132991","volume":"88","year":"1980","journal-title":"Journal of Biochemistry"},{"issue":"11","key":"27","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/0041-0101(87)90136-X","volume":"25","year":"1987","journal-title":"Toxicon"},{"issue":"5628","key":"28","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/269521a0","volume":"269","year":"1977","journal-title":"Nature"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2006.01.009"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2005.08.011"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2004.11.004"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FP0060298"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706352"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050202"},{"issue":"3","key":"35","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1042\/bj2700737","volume":"270","year":"1990","journal-title":"Biochemical Journal"},{"issue":"1","key":"36","first-page":"289","volume":"286","year":"1998","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"2","key":"37","first-page":"517","volume":"291","year":"1999","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10427"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(95)05729-3"},{"issue":"12","key":"40","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.4049\/jimmunol.149.12.4021","volume":"149","year":"1992","journal-title":"The Journal of Immunology"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1105643"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/206061.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/206061.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/206061.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:09:57Z","timestamp":1687910997000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2013\/206061\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":41,"alternative-id":["206061","206061"],"URL":"https:\/\/doi.org\/10.1155\/2013\/206061","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2013]]}}}